Academic Journal
Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma
| العنوان: | Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma |
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| المؤلفون: | Capdeville, Charles, Russo, Linda, Penton, David, Migliavacca, Jessica, Zecevic, Milica, Gries, Alexandre, Neuhauss, Stephan C F, Grotzer, Michael A, Baumgartner, Martin |
| المصدر: | Capdeville, Charles; Russo, Linda; Penton, David; Migliavacca, Jessica; Zecevic, Milica; Gries, Alexandre; Neuhauss, Stephan C F; Grotzer, Michael A; Baumgartner, Martin (2022). Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma. Life Science Alliance, 5(6):e202201380. |
| بيانات النشر: | Life Science Alliance |
| سنة النشر: | 2022 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Medical Clinic, 570 Life sciences, biology, 610 Medicine & health |
| الوصف: | The composition of the plasma membrane (PM)-associated proteome of tumor cells determines cell-cell and cell-matrix interactions and the response to environmental cues. Whether the PM-associated proteome impacts the phenotype of Medulloblastoma (MB) tumor cells and how it adapts in response to growth factor cues is poorly understood. Using a spatial proteomics approach, we observed that hepatocyte growth factor (HGF)-induced activation of the receptor tyrosine kinase c-MET in MB cells changes the abundance of transmembrane and membrane-associated proteins. The depletion of MAP4K4, a pro-migratory effector kinase downstream of c-MET, leads to a specific decrease of the adhesion and immunomodulatory receptor CD155 and of components of the fast-endophilin-mediated endocytosis (FEME) machinery in the PM-associated proteome of HGF-activated MB cells. The decreased surface expression of CD155 or of the fast-endophilin-mediated endocytosis effector endophilin-A1 reduces growth and invasiveness of MB tumor cells in the tissue context. These data thus describe a novel function of MAP4K4 in the control of the PM-associated proteome of tumor cells and identified two downstream effector mechanisms controlling proliferation and invasiveness of MB cells. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2575-1077 |
| Relation: | https://www.zora.uzh.ch/id/eprint/224574/7/e202201380.full.pdf; https://www.zora.uzh.ch/id/eprint/224574/1/Capdeville_et.al._Life_Sci_alliance_2022_zora.pdf; info:pmid/35296518; urn:issn:2575-1077 |
| DOI: | 10.26508/lsa.202201380 |
| الاتاحة: | https://www.zora.uzh.ch/id/eprint/224574/ https://www.zora.uzh.ch/id/eprint/224574/7/e202201380.full.pdf https://www.zora.uzh.ch/id/eprint/224574/1/Capdeville_et.al._Life_Sci_alliance_2022_zora.pdf https://doi.org/10.26508/lsa.202201380 |
| Rights: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.C70892B8 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 25751077 |
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| DOI: | 10.26508/lsa.202201380 |