Academic Journal
Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation
| العنوان: | Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation |
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| المؤلفون: | Reiner, Martin F, Bertschi, Daniela A, Werlen, Laura, Wiencierz, Andrea, Aeschbacher, Stefanie, Lee, Pratintip, Rodondi, Nicolas, Moutzouri, Elisavet, Bonati, Leo, Reichlin, Tobias, Moschovitis, Giorgio, Rutishauser, Jonas, Kühne, Michael, Osswald, Stefan, Conen, David, Beer, Jürg H |
| المصدر: | Reiner, Martin F; Bertschi, Daniela A; Werlen, Laura; Wiencierz, Andrea; Aeschbacher, Stefanie; Lee, Pratintip; Rodondi, Nicolas; Moutzouri, Elisavet; Bonati, Leo; Reichlin, Tobias; Moschovitis, Giorgio; Rutishauser, Jonas; Kühne, Michael; Osswald, Stefan; Conen, David; Beer, Jürg H (2024). Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation. Nutrients, 16(2):178. |
| بيانات النشر: | MDPI Publishing |
| سنة النشر: | 2024 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Center for Molecular Cardiology, 610 Medicine & health |
| الوصف: | Omega-3 fatty acids (n-3 FAs) are associated with a lower risk of ischemic stroke in patients with atrial fibrillation (AF). Antithrombotic mechanisms may in part explain this observation. Therefore, we examined the association of n-3 FAs with D-dimer and beta-thromboglobulin (BTG), markers for activated coagulation and platelets, respectively. The n-3 FAs eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and alpha-linolenic acid (ALA) were determined via gas chromatography in the whole blood of 2373 patients with AF from the Swiss Atrial Fibrillation cohort study (ClinicalTrials.gov Identifier: NCT02105844). In a cross-sectional analysis, we examined the association of total n-3 FAs (EPA + DHA + DPA + ALA) and the association of individual fatty acids with D-dimer in patients with detectable D-dimer values (n = 1096) as well as with BTG (n = 2371) using multiple linear regression models adjusted for confounders. Median D-dimer and BTG levels were 0.340 ug/mL and 448 ng/mL, respectively. Higher total n-3 FAs correlated with lower D-dimer levels (coefficient 0.94, 95% confidence interval (Cl) 0.90–0.98, p = 0.004) and lower BTG levels (coefficient 0.97, Cl 0.95–0.99, p = 0.003). Likewise, the individual n-3 FAs EPA, DHA, DPA and ALA showed an inverse association with D-dimer. Higher levels of DHA, DPA and ALA correlated with lower BTG levels, whereas EPA showed a positive association with BTG. In patients with AF, higher levels of n-3 FAs were associated with lower levels of D-dimer and BTG, markers for activated coagulation and platelets, respectively. These findings suggest that n-3 FAs may exert antithrombotic properties in patients with AF. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| Relation: | https://www.zora.uzh.ch/id/eprint/262403/1/ZORA_pdf_version_1704429021.pdf; info:pmid/38257071; urn:issn:2072-6643 |
| DOI: | 10.3390/nu16020178 |
| الاتاحة: | https://www.zora.uzh.ch/id/eprint/262403/ https://www.zora.uzh.ch/id/eprint/262403/1/ZORA_pdf_version_1704429021.pdf https://doi.org/10.3390/nu16020178 |
| Rights: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.C70402F7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726643 |
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| DOI: | 10.3390/nu16020178 |