Academic Journal
Evolution of treatment paradigms in neovascular age-related macular degeneration: a review of real-world evidence
| العنوان: | Evolution of treatment paradigms in neovascular age-related macular degeneration: a review of real-world evidence |
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| المؤلفون: | Daien, V, Finger, RP, Talks, JS, Mitchell, P, Wong, TY, Sakamoto, T, Eldem, BM, Korobelnik, J-F |
| بيانات النشر: | BMJ PUBLISHING GROUP |
| سنة النشر: | 2021 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | The aim of this work was to evaluate the contribution of real-world evidence (RWE) in changing anti-vascular endothelial growth factor (VEGF) therapy treatment practices and improving real-world treatment strategies for neovascular age-related macular degeneration (nAMD).A PubMed literature search was performed to review the large number of English-language studies conducted to investigate the real-world effectiveness of anti-VEGF (aflibercept and ranibizumab) treatment paradigms available for nAMD.The evidence for pro re nata (PRN), treat-and-extend (T&E) and fixed bimonthly dosing regimens for anti-VEGF treatment of nAMD were reviewed and findings are summarised. RWE demonstrated that T&E regimens optimise visual outcomes while reducing burden on patients, clinics and physicians, compared with both fixed-dose and PRN regimens.RWE has helped to develop and improve real-world treatment strategies in nAMD, with the aim of optimising visual outcomes and reducing treatment burden in clinical practice. Of the various regimens, a T&E regimen is most likely to adequately balance clinical outcomes and treatment burden for patients with nAMD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0007-1161 1468-2079 |
| Relation: | pii: bjophthalmol-2020-317434; Daien, V., Finger, R. P., Talks, J. S., Mitchell, P., Wong, T. Y., Sakamoto, T., Eldem, B. M. & Korobelnik, J. -F. (2021). Evolution of treatment paradigms in neovascular age-related macular degeneration: a review of real-world evidence. BRITISH JOURNAL OF OPHTHALMOLOGY, 105 (11), pp.1475-1479. https://doi.org/10.1136/bjophthalmol-2020-317434.; http://hdl.handle.net/11343/306221 |
| الاتاحة: | http://hdl.handle.net/11343/306221 |
| Rights: | CC BY-NC ; https://creativecommons.org/licenses/by-nc/4.0 |
| رقم الانضمام: | edsbas.C6E20D4A |
| قاعدة البيانات: | BASE |
| تدمد: | 00071161 14682079 |
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