Academic Journal
Neurosarcoidosis Presenting with Prominent Periventricular White-Matter Lesions during Steroid Treatment for Autoimmune Hepatitis
| العنوان: | Neurosarcoidosis Presenting with Prominent Periventricular White-Matter Lesions during Steroid Treatment for Autoimmune Hepatitis |
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| المؤلفون: | Shibahara, Tomoya, Yoshino, Fumitaka, Matsuoka, Mikiaki, Tachibana, Masaki, Nakamura, Kuniyuki, Ago, Tetsuro, Kuroda, Junya, Nakane, Hiroshi |
| المصدر: | Case Reports in Neurology ; volume 14, issue 2, page 334-340 ; ISSN 1662-680X |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2022 |
| الوصف: | A 63-year-old woman under treatment of autoimmune hepatitis presented with headache, memory loss, and somnolence. Three months before admission, the patient experienced liver inflammation relapse after prednisolone (PSL) cessation. Consequently, PSL was resumed and then tapered. Cerebrospinal fluid (CSF) examination showed lymphocytic pleocytosis with remarkably reduced glucose and elevated angiotensin-converting enzyme and soluble interleukin-2 receptor levels. Magnetic resonance imaging (MRI) revealed prominent bilateral periventricular white-matter lesions, hydrocephalus, ischemic stroke with gadolinium enhancement of frontoparietal and basilar meninges on contrast-enhanced fluid-attenuated inversion recovery. Magnetic resonance angiography (MRA) showed narrowing of the bilateral middle cerebral arteries. Based on these findings, we diagnosed the patient with neurosarcoidosis. Re-increment of PSL improved the neurological symptoms, CSF findings, and abnormalities found on MRI and MRA. This case suggests that neurosarcoidosis may occur as a complication of some autoimmune diseases during immunotherapy administration. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000526223 |
| الاتاحة: | http://dx.doi.org/10.1159/000526223 https://www.karger.com/Article/Pdf/526223 |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ ; https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.C6D20334 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000526223 |
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