Academic Journal
Docking Proteins Upregulate IL-1β Expression in Lower Esophageal Sphincter Muscle in Esophageal Achalasia
| العنوان: | Docking Proteins Upregulate IL-1β Expression in Lower Esophageal Sphincter Muscle in Esophageal Achalasia |
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| المؤلفون: | Tsutomu Kanda, Karen Saiki, Hiroki Kurumi, Akira Yoshida, Yuichiro Ikebuchi, Takuki Sakaguchi, Shigetoshi Urabe, Hitomi Minami, Naoyuki Yamaguchi, Kazuhiko Nakao, Haruhiro Inoue, Hajime Isomoto |
| المصدر: | Journal of Clinical Medicine, Vol 13, Iss 10, p 3004 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | esophageal achalasia, peroral endoscopic myotomy, herpes simplex virus type 1, docking proteins 1 and 2, IL-1β, Medicine |
| الوصف: | Background/Objectives: Esophageal achalasia is an archetypal esophageal motility disorder characterized by abnormal peristalsis of the esophageal body and impaired lower esophageal sphincter (LES) relaxation. Methods: In this study, the mRNA expression of docking proteins 1 and 2 ( DOK1 and DOK2 , respectively) were analyzed and the mechanisms underlying achalasia onset were investigated. Results: DOK1 and DOK2 mRNA levels significantly increased in the LES of patients with achalasia. Moreover, significant correlations were observed between IL-1β and DOK1 , IL-1β and DOK2 , ATG16L1 and DOK1 , and HSV1-miR-H1-3p and DOK2 expression levels. However, a correlation between ATG16L1 and DOK2 or between HSV-miR-H1-3p and DOK1 expression was not observed. In addition, a positive correlation was observed between patient age and DOK1 expression. Microarray analysis revealed a significant decrease in the expression of hsa-miR-377-3p and miR-376a-3p in the LES muscle of patients with achalasia. Conclusions: These miRNAs possessed sequences targeting DOK. The upregulation of DOK1 and DOK2 expression induces IL-1β expression in the LES of achalasia patients, which may contribute to the development of esophageal motility disorder. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2077-0383 |
| Relation: | https://www.mdpi.com/2077-0383/13/10/3004; https://doaj.org/toc/2077-0383; https://doaj.org/article/6bd7e92e6c564fcba7fc6992158d3ca6 |
| DOI: | 10.3390/jcm13103004 |
| الاتاحة: | https://doi.org/10.3390/jcm13103004 https://doaj.org/article/6bd7e92e6c564fcba7fc6992158d3ca6 |
| رقم الانضمام: | edsbas.C6CD7AD9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20770383 |
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| DOI: | 10.3390/jcm13103004 |