Data_Sheet_1_Effects of Lactiplantibacillus plantarum 19-2 on immunomodulatory function and gut microbiota in mice.ZIP
| العنوان: | Data_Sheet_1_Effects of Lactiplantibacillus plantarum 19-2 on immunomodulatory function and gut microbiota in mice.ZIP |
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| المؤلفون: | Xiaoran Wang, Jilang Tang, Shixia Zhang, Nuannuan Zhang |
| سنة النشر: | 2022 |
| المجموعة: | Frontiers: Figshare |
| مصطلحات موضوعية: | Microbiology, Microbial Genetics, Microbial Ecology, Mycology, Lactiplantibacillus plantarum, immunomodulatory, immune globulin, cytokine, intestinal microbiota |
| الوصف: | This study aims to evaluate the effects of Lactiplantibacillus plantarum 19-2 (L. plantarum 19-2) on mice treated with the alkylating agent cyclophosphamide (CTX). Our findings show that L. plantarum 19-2 restored the spleen and thymus index and the number of white blood cells and lymphocytes% in CTX treated mice. Serum immunoglobulin levels in CTX-treated mice were increased by L. plantarum 19-2. In addition, as compared to the model group, L. plantarum 19-2 upregulated the content of SIgA, while L. plantarum 19-2 regulates the mRNA and protein expression levels of GATA-3, T-bet, IFN-γ, and IL-4 in small intestinal tissues, which adjusted mucosal barriers, structural status, and the balance of Helper T-cell 1 and Helper T-cell 2. Lactiplantibacillus plantarum 19-2 regulated the distribution of intestinal flora in mice, promoting the growth of Bacteroides and Proteobacteria. In addition, L. plantarum 19-2 inhibited the growth of several harmful bacteria, including Actinobacteria and Firmicutes. |
| نوع الوثيقة: | dataset |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/dataset/Data_Sheet_1_Effects_of_Lactiplantibacillus_plantarum_19-2_on_immunomodulatory_function_and_gut_microbiota_in_mice_ZIP/20430144 |
| DOI: | 10.3389/fmicb.2022.926756.s001 |
| الاتاحة: | https://doi.org/10.3389/fmicb.2022.926756.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Effects_of_Lactiplantibacillus_plantarum_19-2_on_immunomodulatory_function_and_gut_microbiota_in_mice_ZIP/20430144 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.C6C7499B |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fmicb.2022.926756.s001 |
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