Academic Journal
PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development
| العنوان: | PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development |
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| المؤلفون: | Mei Yu, Yuhong Chen, Hu Zeng, Yongwei Zheng, Guoping Fu, Wen Zhu, Ulrich Broeckel, Praful Aggarwal, Amy Turner, Geoffrey Neale, Cliff Guy, Nan Zhu, Hongbo Chi, Renren Wen, Demin Wang |
| المصدر: | Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017) |
| بيانات النشر: | Nature Portfolio |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Science |
| الوصف: | IL-7R activation drives early B cell development, but the signalling is unclear. Here the authors show PLCγ is involved in IL-7R-induced mTOR activation via a DAG/PKC-dependent pathway, and that double deficiency of the two PLCγ isoforms arrests B cell development at the pre-pro-B stage in mice. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-1723 |
| Relation: | https://doi.org/10.1038/s41467-017-01388-5; https://doaj.org/toc/2041-1723; https://doaj.org/article/c452dfc952154a9d82178c4541f18fa3 |
| DOI: | 10.1038/s41467-017-01388-5 |
| الاتاحة: | https://doi.org/10.1038/s41467-017-01388-5 https://doaj.org/article/c452dfc952154a9d82178c4541f18fa3 |
| رقم الانضمام: | edsbas.C6C32965 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-017-01388-5 |