Academic Journal
Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells.
| العنوان: | Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. |
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| المؤلفون: | Meier, D., Bornmann, C., Chappaz, S., Schmutz, S., Otten, L.A., Ceredig, R., Acha-Orbea, H., Finke, D. |
| المصدر: | Immunity, vol. 26, no. 5, pp. 643-654 |
| سنة النشر: | 2007 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Animals, Cell Differentiation/immunology, Cell Survival, Cells, Cultured, Fetus/metabolism, Gene Expression Regulation, Interleukin-7/genetics, Interleukin-7/metabolism, Lymphoid Tissue/cytology, Lymphoid Tissue/immunology, Mice, Transgenic, Stem Cells/cytology, Stem Cells/metabolism, T-Lymphocytes, Helper-Inducer/cytology, Helper-Inducer/immunology, Vascular Cell Adhesion Molecule-1/metabolism |
| الوصف: | Development of Peyer's patches and lymph nodes requires the interaction between CD4+ CD3- IL-7Ralpha+ lymphoid-tissue inducer (LTi) and VCAM-1+ organizer cells. Here we showed that by promoting their survival, enhanced expression of interleukin-7 (IL-7) in transgenic mice resulted in accumulation of LTi cells. With increased IL-7 availability, de novo formation of VCAM-1+ Peyer's patch anlagen occurred along the entire fetal gut resulting in a 5-fold increase in Peyer's patch numbers. IL-7 overexpression also led to formation of multiple organized ectopic lymph nodes and cecal patches. After immunization, ectopic lymph nodes developed normal T cell-dependent B cell responses and germinal centers. Mice overexpressing IL-7 but lacking either RORgamma, a factor required for LTi cell generation, or lymphotoxin alpha1beta2 had neither Peyer's patches nor ectopic lymph nodes. Therefore, by controlling LTi cell numbers, IL-7 can regulate the formation of both normal and ectopic lymphoid organs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/17521585; info:eu-repo/semantics/altIdentifier/pissn/1074-7613; https://serval.unil.ch/notice/serval:BIB_EA39B416A11C |
| DOI: | 10.1016/j.immuni.2007.04.009 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_EA39B416A11C https://doi.org/10.1016/j.immuni.2007.04.009 |
| رقم الانضمام: | edsbas.C68BE3D7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.immuni.2007.04.009 |
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