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Dual-task related frontal cerebral blood flow changes in older adults with mild cognitive impairment: A functional diffuse correlation spectroscopy study

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العنوان: Dual-task related frontal cerebral blood flow changes in older adults with mild cognitive impairment: A functional diffuse correlation spectroscopy study
المؤلفون: Udina Argilaga, Cristina, Avtzi, Stella, Mota Foix, Miriam, Rosso, Andrea, Ars Ricart, Joan, Frisk, Lisa Kobayashi, Inzitari, Marco
المساهمون: Institut Català de la Salut, Udina C, Ars J REFiT Barcelona Research Group, Parc Sanitari Pere Virgili, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Avtzi S, Kobayashi Frisk L ICFO – Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Barcelona, Spain. Mota-Foix M Unitat d'Estadística i Bioinformàtica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Rosso AL Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States. Inzitari M REFiT Barcelona Research Group, Parc Sanitari Pere Virgili, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Faculty of Health Sciences, Universitat Oberta de Catalunya (UOC), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
المصدر: Scientia
بيانات النشر: Frontiers Media
سنة النشر: 2022
مصطلحات موضوعية: Circulació cerebral, Trastorns de la cognició, PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurocognitive Disorders::Cognition Disorders::Cognitive Dysfunction, PHENOMENA AND PROCESSES::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Blood Circulation::Cerebrovascular Circulation, PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos neurocognitivos::trastornos cognitivos::disfunción cognitiva, FENÓMENOS Y PROCESOS::fenómenos fisiológicos respiratorios y circulatorios::fenómenos fisiológicos cardiovasculares::circulación sanguínea::circulación cerebrovascular
الوصف: Cerebral blood flow; Mild cognitive impairment; Spectroscopy ; Flux sanguini cerebral; Deteriorament cognitiu lleu; Espectroscòpia ; Flujo sanguíneo cerebral; Deterioro cognitivo leve; Espectroscopia ; Introduction: In a worldwide aging population with a high prevalence of motor and cognitive impairment, it is paramount to improve knowledge about underlying mechanisms of motor and cognitive function and their interplay in the aging processes. Methods: We measured prefrontal cerebral blood flow (CBF) using functional diffuse correlation spectroscopy during motor and dual-task. We aimed to compare CBF changes among 49 older adults with and without mild cognitive impairment (MCI) during a dual-task paradigm (normal walk, 2- forward count walk, 3-backward count walk, obstacle negotiation, and heel tapping). Participants with MCI walked slower during the normal walk and obstacle negotiation compared to participants with normal cognition (NC), while gait speed during counting conditions was not different between the groups, therefore the dual-task cost was higher for participants with NC. We built a linear mixed effects model with CBF measures from the right and left prefrontal cortex. Results: MCI (n = 34) showed a higher increase in CBF from the normal walk to the 2-forward count walk (estimate = 0.34, 95% CI [0.02, 0.66], p = 0.03) compared to participants with NC, related to a right- sided activation. Both groups showed a higher CBF during the 3-backward count walk compared to the normal walk, while only among MCI, CFB was higher during the 2-forward count walk. Discussion: Our findings suggest a differential prefrontal hemodynamic pattern in older adults with MCI compared to their NC counterparts during the dual-task performance, possibly as a response to increasing attentional demand. ; This work was supported by the Instituto de Salud Carlos III (MEDPHOTAGE, DTS 16/00099 and DTS 16/00087, 2017, and FRONT STAGE, PI 19/00734, 2020) and co-funded by European Regional Development Fund/European Social Fund ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 1663-4365
Relation: Frontiers in Aging Neuroscience;14; https://doi.org/10.3389/fnagi.2022.958656; info:eu-repo/grantAgreement/ES/PE2013-2016/DTS16%2F00099; info:eu-repo/grantAgreement/EC/H2020/713729; info:eu-repo/grantAgreement/EC/H2020/871124; Udina C, Avtzi S, Mota-Foix M, Rosso AL, Ars J, Kobayashi Frisk L, et al. Dual-task related frontal cerebral blood flow changes in older adults with mild cognitive impairment: A functional diffuse correlation spectroscopy study. Front Aging Neurosci. 2022 Dec 20;14:958656.; https://hdl.handle.net/11351/8944; 000905734300001
DOI: 10.3389/fnagi.2022.958656
الاتاحة: https://hdl.handle.net/11351/8944
https://doi.org/10.3389/fnagi.2022.958656
Rights: Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.C668A911
قاعدة البيانات: BASE
الوصف
تدمد:16634365
DOI:10.3389/fnagi.2022.958656