التفاصيل البيبلوغرافية
| العنوان: |
Cortisol Stress Biosensor Based on Molecular Imprinted Polymer |
| المؤلفون: |
Supannika Klangphukhiew, Roongnapa Srichana, Rina Patramanon |
| المصدر: |
Proceedings; Volume 1; Issue 4; Pages: 538 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2017 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
core shell molecular imprinted polymer (Cs-MIP), cortisol, screen printed carbon electrode (SPCE) |
| الوصف: |
The molecular imprinted polymer (MIP) technique was applied to receptors that could imitate the performance of natural anti-cortisol antibody with high stability. Cortisol-molecular imprinted polymer (cortisol-MIP) was obtained using the multi-step swelling and polymerization protocol with cortisol as a target molecule. The suitable ratio of methacrylic acid:acrylamide :cortisol which allowed the formation of 642.3 ± 35.8 nm homogenous particles was 2:1:1. Cortisol-MIP was integrated to the sensor. It was coated on the disposable screen-printed carbon electrode (SPCE) for portable electrochemical analysis. The physical properties of Cortisol-MIP were characterized by means of electron microscope techniques. The binding characteristics were evaluated via covalent patterns changing in FTIR spectra which were related to voltammetry responses. The SPCE modified with cortisol-MIP was able to perform various detection ranges from 1.28 to 20 nM and the high selectivity compared to three other glucocorticoid analogs. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://dx.doi.org/10.3390/proceedings1040538 |
| DOI: |
10.3390/proceedings1040538 |
| الاتاحة: |
https://doi.org/10.3390/proceedings1040538 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.C61429DC |
| قاعدة البيانات: |
BASE |