Academic Journal
Macrophages co-loaded with drug-associated and superparamagnetic nanoparticles for triggered drug release by alternating magnetic fields ...
| العنوان: | Macrophages co-loaded with drug-associated and superparamagnetic nanoparticles for triggered drug release by alternating magnetic fields ... |
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| المؤلفون: | Desai, Omkar, Kumar, Sandhya, Köster, Mario, Ullah, Sami, Sarker, Sushobhan, Hagemann, Valentin, Habib, Mosaieb, Klaassen, Nicole, Notter, Silke, Feldmann, Claus, Ehlert, Nina, Hauser, Hansjörg, Wirth, Dagmar |
| بيانات النشر: | Springer |
| سنة النشر: | 2025 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| الوصف: | Two features of macrophages make them attractive for targeted transport of drugs: they efficiently take up a broad spectrum of nanoparticles (NPs) and, by sensing cytokine gradients, they are attracted to the sites of infection and inflammation. To expand the potential of macrophages as drug carriers, we investigated whether macrophages could be simultaneously coloaded with different types of nanoparticles, thus equipping individual cells with different functionalities. We used superparamagnetic iron oxide NPs (SPIONs), which produce apoptosis-inducing hyperthermia when exposed to an alternating magnetic field (AMF), and co-loaded them on macrophages together with drug-containing NPs (inorganic–organic nanoparticles (IOH-NPs) or mesoporous silica NPs (MSNs)). We show that individual macrophages can take up both SPIONs and drug-loaded NPs efficiently, thereby generating drug-loaded cells susceptible to AMF-induced cell death. Macrophages co-loaded with SPIONs and drug-containing IOH-NPs spontaneously released ... |
| نوع الوثيقة: | article in journal/newspaper text |
| اللغة: | English |
| DOI: | 10.5445/ir/1000178464 |
| الاتاحة: | https://dx.doi.org/10.5445/ir/1000178464 https://publikationen.bibliothek.kit.edu/1000178464 |
| Rights: | Creative Commons Namensnennung 4.0 International ; Open Access ; info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by/4.0/deed.de |
| رقم الانضمام: | edsbas.C5E44F30 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5445/ir/1000178464 |
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