Academic Journal
Clinical Significance of Pepsinogen C Tumor Expression in Patients with Stage D2 Prostate Carcinoma
| العنوان: | Clinical Significance of Pepsinogen C Tumor Expression in Patients with Stage D2 Prostate Carcinoma |
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| المؤلفون: | Díaz, M., Rodríguez, J.C., Sánchez, J., Sánchez, M.T., Martín, A., Merino, A.M., Vizoso, F. |
| المصدر: | The International Journal of Biological Markers ; volume 17, issue 2, page 125-129 ; ISSN 0393-6155 1724-6008 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2002 |
| الوصف: | Pepsinogen C is an aspartyl protease mainly involved in the digestion of proteins in the stomach, and an androgen-inducible protein in breast cancer cells. The aims of this study were to evaluate the expression and clinical significance of this enzyme in the primary tumors of prostate cancer patients with bone metastasis who were scheduled to receive antiandrogenic therapy. This study was prospectively performed in 28 stage D2 prostate cancer patients who, after diagnosis, received maximum androgen blockade. Pepsinogen C tumor expression was analyzed in samples (24 from needle biopsy cylinders and four from transurethral resection specimens) from primary tumors using an immunohistochemical assay. Twelve prostate carcinomas (42.8%) were positive for pepsinogen C. Pepsinogen C was a significant prognostic factor to predict a longer overall survival in the patients of our study (p<0.01). Pepsinogen C can be a new prognostic factor and a useful biological marker of androgen dependency in prostate cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/172460080201700208 |
| الاتاحة: | https://doi.org/10.1177/172460080201700208 https://journals.sagepub.com/doi/pdf/10.1177/172460080201700208 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.C5B50B49 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/172460080201700208 |
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