Academic Journal
Survival in Pediatric Dialysis and Transplant Patients
| العنوان: | Survival in Pediatric Dialysis and Transplant Patients |
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| المؤلفون: | Samuel, Susan M., Tonelli, Marcello A., Foster, Bethany J., Alexander, R. Todd, Nettel-Aguirre, Alberto, Soo, Andrea, Hemmelgarn, Brenda R. |
| المصدر: | Clinical Journal of the American Society of Nephrology ; volume 6, issue 5, page 1094-1099 ; ISSN 1555-9041 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2011 |
| الوصف: | Summary Background and objectives Long-term follow-up data are few in children with ESRD. We sought to describe long-term survival, assess risk factors for death, and compare survival between two time periods in pediatric ESRD patients. Design, setting, participants, & measurements We used a population-based retrospective cohort utilizing data from a national organ failure registry and from Canada's universal healthcare system. We included 843 children (ages, 0 to 18) initiating renal replacement therapy from 1992 to 2007 and followed them until death or date of last contact (median follow-up, 6.8 years; interquartile range, 3.0 to 10.6). We assessed risk factors for death and examined cause-specific mortality. Results During 5991 patient-years of follow-up, 107 (12.7%) patients died. Unadjusted cumulative survival for the cohort was: 91.7% (95% CI, 89.8 to 93.7%) at 5 years and 85.8% (95% CI, 82.8 to 88.8%) at 10 years. Among patients commencing dialysis, overall adjusted survival was poorest among those who started dialysis at age <1 year. No secular trends in survival were noted for either dialysis or transplant patients. The proportion of incident patients receiving pre-emptive transplantation increased over time. Pre-emptively transplanted patients did not demonstrate superior adjusted survival compared with those who spent >2 years on dialysis before transplant (hazard ratio, 1.53; 95% CI, 0.63 to 3.67). Conclusions No significant improvements in survival were observed among ESRD patients over the study period. Time with transplant function had the strongest association with survival. Pre-emptive transplantation was not associated with improved survival in adjusted models. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.2215/cjn.04920610 |
| الاتاحة: | http://dx.doi.org/10.2215/cjn.04920610 https://journals.lww.com/01277230-201105000-00021 |
| رقم الانضمام: | edsbas.C57984EC |
| قاعدة البيانات: | BASE |
| DOI: | 10.2215/cjn.04920610 |
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