Academic Journal
European journal of pharmaceutics and biopharmaceutics / Digestion of lipid excipients and lipid-based nanocarriers by pancreatic lipase and pancreatin
| العنوان: | European journal of pharmaceutics and biopharmaceutics / Digestion of lipid excipients and lipid-based nanocarriers by pancreatic lipase and pancreatin |
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| المؤلفون: | Zöller, Katrin, To, Dennis, Knoll, Patrick, Bernkop-Schnürch, Andreas |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | University of Innsbruck: Digital Library (Universitäts- und Landesbibliothek Tirol) |
| مصطلحات موضوعية: | Lipolysis, Lipase, Pancreatin, Lipid-based nanocarriers, Self-emulsifying drug delivery systems, Solid lipid nanocarriers, Nanostructured lipid carriers |
| جغرافية الموضوع: | UI:AE:MN, UI:CP:AB |
| الوصف: | The digestion behaviour of lipid-based nanocarriers (LNC) has a great impact on their oral drug delivery properties. In this study, various excipients including surfactants, glycerides and waxes, as well as various drug-delivery systems, namely self-emulsifying drug delivery systems (SEDDS), solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were examined via the pH-stat lipolysis model. Lipolysis experiments with lipase and pancreatin revealed the highest release of fatty acids for medium chain glycerides, followed by long chain glycerides and surfactants. Waxes appeared to be poor substrates with a maximum digestion of up to 10% within 60 min. Within the group of surfactants, the enzymatic cleavage decreased in the following order: glycerol monostearate > polyoxyethylene (20) sorbitan monostearate > PEG-35 castor oil > sorbitan monostearate. After digestion experiments of the excipients, SEDDS, SLN and NLC with sizes between 30 and 300 nm were prepared. The size of almost all formulations was increasing during lipolysis and levelled off after approximately 15 min except for the SLN and NLC consisting of cetyl palmitate. SEDDS exceeded 6000 nm after some minutes and were almost completely hydrolysed by pancreatin. No significant difference was observed between comparable SLN and NLC but surfactant choice and selection of the lipid component had an impact on digestion. SLN and NLC with cetyl palmitate were only digested by 5% whereas particles with glyceryl distearate were decomposed by 40–80% within 60 min. Additionally, the digestion of the same SLN or NLC, only differing in the surfactant, was higher for SLN/NLC containing polyoxyethylene (20) sorbitan monostearate than PEG-35 castor oil. This observation might be explained by the higher PEG content of PEG-35 castor oil causing a more pronounced steric hindrance for the access of lipase. Generally, digestion experiments performed with pancreatin resulted in a higher digestion compared to lipase. According to these results, the ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 0939-6411 |
| Relation: | vignette : https://diglib.uibk.ac.at/titlepage/urn/urn:nbn:at:at-ubi:3-26732/128; urn:nbn:at:at-ubi:3-26732; https://resolver.obvsg.at/urn:nbn:at:at-ubi:3-26732; local:99146928641803331; system:AC16604645 |
| DOI: | 10.1016/j.ejpb.2022.05.003 |
| الاتاحة: | https://doi.org/10.1016/j.ejpb.2022.05.003 https://diglib.uibk.ac.at/doi/10.1016/j.ejpb.2022.05.003 https://resolver.obvsg.at/urn:nbn:at:at-ubi:3-26732 |
| Rights: | cc-by_4 |
| رقم الانضمام: | edsbas.C55013B5 |
| قاعدة البيانات: | BASE |
| تدمد: | 09396411 |
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| DOI: | 10.1016/j.ejpb.2022.05.003 |