Academic Journal
Twenty-Four Hour Blood Pressure Response to Empagliflozin and Its Determinants in Normotensive Non-diabetic Subjects.
| العنوان: | Twenty-Four Hour Blood Pressure Response to Empagliflozin and Its Determinants in Normotensive Non-diabetic Subjects. |
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| المؤلفون: | Zanchi, A., Pruijm, M., Muller, M.E., Ghajarzadeh-Wurzner, A., Maillard, M., Dufour, N., Bonny, O., Wuerzner, G., Burnier, M. |
| المصدر: | Frontiers in cardiovascular medicine, vol. 9, pp. 854230 |
| سنة النشر: | 2022 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | ABPM - 24-h ambulatory blood pressure monitoring, SGLT2 (sodium-glucose cotransporter 2) inhibitor, blood pressure, empagliflozin, healthy volunteer, normotension |
| الوصف: | Sodium-glucose co-transport 2 inhibitors (SGLT2i) lower blood pressure (BP) in normotensive subjects and in hypertensive and normotensive diabetic and non-diabetic patients. However, the mechanisms of these BP changes are not fully understood. Therefore, we examined the clinical and biochemical determinants of the BP response to empagliflozin based on 24-h ambulatory BP monitoring. In this post-hoc analysis of a double-blind, randomized, placebo-controlled study examining the renal effects of empagliflozin 10 mg vs. placebo in untreated normotensive non-diabetic subjects, the 1-month changes in 24 h ambulatory BP were analyzed in 39 subjects (13 placebo/26 empagliflozin) in regard to changes in biochemical and hormonal parameters. At 1 month, empagliflozin 10 mg decreased 24-h systolic (SBP) and diastolic (DBP) BP significantly by -5 ± 7 mmHg (p < 0.001) and -2 ± 6 mmHg (p = 0.03). The effect on SBP and DBP was more pronounced during nighttime (resp. -6 ± 11 mmHg, p = 0.004; -4 ± 7 mmHg, p = 0.007). The main determinants of daytime and nighttime SBP and DBP responses were baseline BP levels (for daytime SBP: coefficient -0.5; adj. R 2 : 0.36; p = 0.0007; for night-time SBP: coefficient -0.6; adj. R 2 : 0.33; p = 0.001). Although empaglifozin induced significant biochemical changes, none correlated with blood pressure changes including urinary sodium, lithium, glucose and urate excretion and free water clearance. Plasma renin activity and plasma aldosterone levels increased significantly at 1 month suggesting plasma volume contraction, while plasma metanephrine and copeptin levels remained the same. Renal resistive indexes did not change with empagliflozin. SGLT2 inhibition lowers daytime and nighttime ambulatory systolic and diastolic BP in normotensive non-diabetic subjects. Twenty-four jour changes are pronounced and comparable to those described in diabetic or hypertensive subjects. Baseline ambulatory BP was the only ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35391843; info:eu-repo/semantics/altIdentifier/pissn/2297-055X; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_6281EA6B3D3F7; https://serval.unil.ch/notice/serval:BIB_6281EA6B3D3F; https://serval.unil.ch/resource/serval:BIB_6281EA6B3D3F.P001/REF.pdf |
| DOI: | 10.3389/fcvm.2022.854230 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_6281EA6B3D3F https://doi.org/10.3389/fcvm.2022.854230 https://serval.unil.ch/resource/serval:BIB_6281EA6B3D3F.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_6281EA6B3D3F7 |
| Rights: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.C535094D |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fcvm.2022.854230 |
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