Academic Journal
ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice.
| العنوان: | ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice. |
|---|---|
| المؤلفون: | Peng, Z., Ziros, P.G., Martini, T., Liao, X.H., Stoop, R., Refetoff, S., Albrecht, U., Sykiotis, G.P., Kellenberger, S. |
| المصدر: | Communications biology, vol. 6, no. 1, pp. 857 |
| سنة النشر: | 2023 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Animals, Mice, Acid Sensing Ion Channels/genetics, Body Temperature, Energy Metabolism/genetics, Hypothalamus, RNA, Messenger |
| الوصف: | The body temperature of mice is higher at night than during the day. We show here that global deletion of acid-sensing ion channel 1a (ASIC1a) results in lower body temperature during a part of the night. ASICs are pH sensors that modulate neuronal activity. The deletion of ASIC1a decreased the voluntary activity at night of mice that had access to a running wheel but did not affect their spontaneous activity. Daily rhythms of thyrotropin-releasing hormone mRNA in the hypothalamus and of thyroid-stimulating hormone β mRNA in the pituitary, and of prolactin mRNA in the hypothalamus and pituitary were suppressed in ASIC1a -/- mice. The serum thyroid hormone levels were however not significantly changed by ASIC1a deletion. Our findings indicate that ASIC1a regulates activity and signaling in the hypothalamus and pituitary. This likely leads to the observed changes in body temperature by affecting the metabolism or energy expenditure. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37591947; info:eu-repo/semantics/altIdentifier/eissn/2399-3642; info:eu-repo/grantAgreement/SNF//31003A_172968///; info:eu-repo/grantAgreement/SNF//310030_212558///; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_B248EF4DD49B3; https://serval.unil.ch/notice/serval:BIB_B248EF4DD49B; https://serval.unil.ch/resource/serval:BIB_B248EF4DD49B.P001/REF.pdf |
| DOI: | 10.1038/s42003-023-05221-2 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_B248EF4DD49B https://doi.org/10.1038/s42003-023-05221-2 https://serval.unil.ch/resource/serval:BIB_B248EF4DD49B.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_B248EF4DD49B3 |
| Rights: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.C5253D0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s42003-023-05221-2 |
|---|