Academic Journal
Metabolic response of intestinal microbiota to guar gum consumption
| العنوان: | Metabolic response of intestinal microbiota to guar gum consumption |
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| المؤلفون: | Barber Caselles, Claudia, Sabater, Carlos, Guarner, Francisco, Margolles, Abelardo, Azpiroz, Fernando |
| المساهمون: | Institut Català de la Salut, Barber C, Azpiroz F Servei d’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Madrid, Spain. Sabater C, Margolles A Department of Microbiology and Biochemistry, IPLA-CSIC, Asturias, Spain. Health Research Institute of Asturias, ISPA, Asturias, Spain. Guarner F Servei d’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Genòmica, Intestins - Microbiologia, Additius alimentaris, DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics::Metagenomics, PHENOMENA AND PROCESSES::Microbiological Phenomena::Microbiota::Gastrointestinal Microbiome, HEALTH SURVEILLANCE::Health Surveillance of Products::Control and Sanitary Supervision of Foods and Beverages::Food Production::Food Technology::Food Additives::Thickeners, DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::biología::genética::genómica::metagenómica, FENÓMENOS Y PROCESOS::fenómenos microbiológicos::microbiota::microbiota intestinal, VIGILANCIA SANITARIA::control sanitario de productos::control y supervisión sanitaria de alimentos y bebidas::producción de alimentos::tecnología de alimentos::aditivos alimentarios::espesantes |
| الوصف: | Food additive; Guar gum; Prebiotic ; Additiu alimentari; Goma guar; Prebiòtic ; Aditivo alimentario; Goma guar; Prebiótico ; Background: Guar gum is used extensively as a thickening agent in food, but it remains uncertain whether and to what extent it is fermented by colonic microbiota and whether it has microbiota modulatory properties. Aim: To determine the metabolic response of intestinal microbiota to guar gum consumption, specifically, the extent of initial fermentation and subsequent adaptation. Methods: Single-center, single arm, open label, proof-of-concept study testing the effect of guar gum on microbiota metabolism and adaptation. Healthy male subjects (n = 12) were administered gum guar (8 g/day) for 18 days. Outcomes were measured before, at initial and late administration: (a) anal gas evacuations (number/day); (b) digestive sensations (daily scales); and (c) fecal gut microbiota taxonomy and metabolic functions by shotgun sequencing. Results: At initial consumption, guar gum induced a transient increase in anal gas evacuations and digestive sensations; gas evacuation completely reverted upon continuous administration, whereas sensations reverted only in part. Guar gum induced moderate changes in human microbiota composition at both taxonomic and functional levels. Positive associations between effects on microbiota (proliferation of Agathobaculum butyriciproducens and Lachnospira pectinoschiza) and hedonic sensations were detected. Conclusion: Guar gum is metabolized by intestinal microbiota, and, upon continuous consumption, induces a selective adaptation of microbial taxonomy and function. These data highlight the potential interest of guar gum for novel prebiotic ingredient formulation. ; This work was supported in part by the projects PID2021-122295OB-I00 (Ministerio de Ciencia e Innovación, Spain). Ciberehd is funded by the Instituto de Salud Carlos III. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2296-861X |
| Relation: | Frontiers in Nutrition;10; https://doi.org/10.3389/fnut.2023.1160694; info:eu-repo/grantAgreement/ES/PEICTI2021-2023/PID2021-122295OB-I00; Barber C, Sabater C, Guarner F, Margolles A, Azpiroz F. Metabolic response of intestinal microbiota to guar gum consumption. Front Nutr. 2023 Jun 30;10:1160694.; https://hdl.handle.net/11351/10093; 001027888600001 |
| DOI: | 10.3389/fnut.2023.1160694 |
| الاتاحة: | https://hdl.handle.net/11351/10093 https://doi.org/10.3389/fnut.2023.1160694 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C51B3DAA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2296861X |
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| DOI: | 10.3389/fnut.2023.1160694 |