Academic Journal
P-401 The impact of the recipients’ age in vitrified/warmed oocyte donation (OD) cycles
| العنوان: | P-401 The impact of the recipients’ age in vitrified/warmed oocyte donation (OD) cycles |
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| المؤلفون: | Vromman, M, Mackens, S, De Vos, M, Tournaye, H, De Munck, N, Blockeel, C, Drakopoulos, P |
| المصدر: | Human Reproduction ; volume 37, issue Supplement_1 ; ISSN 0268-1161 1460-2350 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| الوصف: | Study question Does female age affect reproductive outcomes in a vitrified/warmed OD program with fresh embryo transfer? Summary answer Oocyte donation performed below the age of 40 was associated with less favorable reproductive outcomes. What is known already It is well established that oocyte and embryo aneuploidy are mainly responsible for the age-related decline in female fertility. Previous studies evaluating the effect of maternal age on implantation potential in OD cycles generated controversial results. It remains unclear whether female age affects reproductive outcome independent of embryo quality. Study design, size, duration This is a retrospective, single tertiary center, cohort study analyzing a vitrified/warmed OD program over a ten-years period (February 2010-February 2020). More specifically, data from 491 unique oocyte recipients were included who performed a fresh embryo transfer after sharing (with at least two recipients) sibling oocytes from the same donor stimulation cycle. For all treatments ICSI was performed without preimplantation genetic testing. Participants/materials, setting, methods The association between recipient’s age and reproductive outcomes was investigated according to three age categories (<35/35-40/>40 years old). The primary outcome was live birth rate (LBR), while the secondary outcome was biochemical pregnancy rate (BPR). A multivariate regression model was developed adjusting for the following covariates (entered simultaneously): recipient’s BMI, recipient’s endometrial thickness, age of the oocyte donor, number of mature oocytes used for ICSI, embryo transfer stage and number of embryos transferred. Main results and the role of chance Mean age of donors was 28.6 years old(±4.1). Mean starting dose was 192.6 IU(±139.9) and duration of stimulation 11.0 days (±1.7). Mean number of collected cumulus oocyte complexes was 25.6(±9.6) and sibling oocytes were assigned to 2, 3 or more recipients in, respectively, 83.1%, 12.4% and 4.5% of cases. Mean ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/humrep/deac107.378 |
| الاتاحة: | https://doi.org/10.1093/humrep/deac107.378 https://academic.oup.com/humrep/article-pdf/37/Supplement_1/deac107.378/44306389/deac107.378.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.C4C1A1A4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/humrep/deac107.378 |
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