Academic Journal
One-year mortality of HIV-positive patients treated for rifampicin-and isoniazid-susceptible tuberculosis in Eastern Europe, Western Europe, and Latin America
| العنوان: | One-year mortality of HIV-positive patients treated for rifampicin-and isoniazid-susceptible tuberculosis in Eastern Europe, Western Europe, and Latin America |
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| المؤلفون: | Karpov, I., Vassilenko, A., Skrahina, A., Klimuk, D., Skrahin, A., Kondratenko, O., Zalutskaya, A., Bondarenko, V., Mitsura, V., Kozorez, E., Tumash, O., Suetnov, O., Paduto, D., Iljina, V., Kummik, T., Bolokadze, N., Mshvidobadze, K., Lanchava, N., Goginashvili, L., Mikiashvili, L., Bablishvili, N., Rozentale, B., Zeltina, I., Janushkevich, I., Caplinskiene, I., Caplinskas, S., Kancauskiene, Z., Podlasin, R., Wiercinska-Drapalo, A., Thompson, M., Kozlowska, J., Grezesczuk, A., Bura, M., Knysz, B., Inglot, M., Garlicki, A., Loster, J., Duiculescu, D., Tetradov, S., Rakhmanova, A., Panteleeva, O., Yakovlev, A., Kozlov, A., Tyukalova, A., Vlasova, Y., Panteleev, A., Trofimova, T., Borodulina, E., Vdoushkina, E., Borodulina, El., Kyselyova, G., Obel, N., Thorsteinsson, K., Payen, M. C., Kabeya, K., Necsoi, C., Dabis, F., Bruyand, M., Morlat, P., Dupont, A., Gerard, Y., Bonnal, F., Ceccaldi, J., De Witte, S., Monlun, E., Lataste, P., Chossat, I., Sagette, M., Rickenbach, M., Elzi, L., Battegay, M., Furrer, H., Sculier, D., Calmy, A., Cavassini, M., Bruno, A., Bernasconi, E., Hoffmann, M., Vernazza, P., Fehr, J., Weber, R., Miller, R. F., Vora, N., Cooke, G., Mullaney, S., Wilkins, E., George, V., Collini, P., Dockrell, D., Post, F., Campbell, L., Brum, R., Mabonga, E., Saigal, P., Kegg, S., Ainsworth, J., Waters, A., Dhar, J., Mashonganyika, L., Girardi, E., Rianda, A., Galati, V., Pinnetti, C., Tommasi, C., Lapadula, G., Di Biagio, A., Parisini, A., Carbonara, S., Angarano, G., Purgatorio, M., Matteelli, A., Apostoli, A., Miro, J. M., Manzardo, C., Ligero, C., Gonzalez, J., Martinez-Martinez, Jose A., Sanchez, F., Knobel, H., Salvado, M., Lopez-Colomes, J. L., Martinez-Lacasa, X., Cuchi, E., Falco, V., Curran, A., Tortola, M. T., Ocana, I., Vidal, R., Sambeat, M. A., Pomar, V., Coll, P., Pozamczer, D., Saumoy, M., Alcaide, F., Cayla, J., Moreno, A., Millet, J. P., Orcau, A., Fina, L., Romero, A., Roldan, L. L., Iribarren, J. A., Ibarguren, M., Moreno, S., Gonzalez, A., Miralles, P., Aldamiz-Echevarria, T., Losso, M., Toibaro, J., Gambardella, L., Macias, L. Moreno, Warley, E., Tavella, S., Messina, O. Garcia, Gear, O., Laplume, H., Marson, C., Contarelia, J., Michaan, M., Scapellato, P., Alessandro, D. D., Bartoletti, B., Palmero, D., Elias, C., Cortes, C., Crabtree, B., Mosqueda Gomez, J. L., Villanueva, J. A., Gonzalez Hernandez, L. A., Badial, F., Cayla, J. A., Lundgren, J. D., Post, F. A., Schultze, A., Mocroft, A., Efsen, A. M. W., Mansfeld, M., Aagaard, B., Nielsen, B. R., Fisher, A. H., Larsen, J. F., Raben, D., Podlekareva, D. N., Kirk, O., Skrahina, A. M., Losso, M. H. |
| المساهمون: | Karpov, I., Vassilenko, A., Skrahina, A., Klimuk, D., Skrahin, A., Kondratenko, O., Zalutskaya, A., Bondarenko, V., Mitsura, V., Kozorez, E., Tumash, O., Suetnov, O., Paduto, D., Iljina, V., Kummik, T., Bolokadze, N., Mshvidobadze, K., Lanchava, N., Goginashvili, L., Mikiashvili, L., Bablishvili, N., Rozentale, B., Zeltina, I., Janushkevich, I., Caplinskiene, I., Caplinskas, S., Kancauskiene, Z., Podlasin, R., Wiercinska-Drapalo, A., Thompson, M., Kozlowska, J., Grezesczuk, A., Bura, M., Knysz, B., Inglot, M., Garlicki, A., Loster, J., Duiculescu, D., Tetradov, S., Rakhmanova, A., Panteleeva, O., Yakovlev, A., Kozlov, A., Tyukalova, A., Vlasova, Y., Panteleev, A., Trofimova, T., Borodulina, E., Vdoushkina, E., Borodulina, El., Kyselyova, G., Obel, N., Thorsteinsson, K., Payen, M. C., Kabeya, K., Necsoi, C., Dabis, F., Bruyand, M., Morlat, P., Dupont, A., Gerard, Y., Bonnal, F., Ceccaldi, J., De Witte, S., Monlun, E., Lataste, P., Chossat, I., Sagette, M., Rickenbach, M., Elzi, L., Battegay, M., Furrer, H., Sculier, D., Calmy, A., Cavassini, M., Bruno, A., Bernasconi, E., Hoffmann, M., Vernazza, P., Fehr, J., Weber, R., Miller, R. F., Vora, N., Cooke, G., Mullaney, S., Wilkins, E., George, V., Collini, P., Dockrell, D., Post, F., Campbell, L., Brum, R., Mabonga, E., Saigal, P., Kegg, S., Ainsworth, J., Waters, A., Dhar, J., Mashonganyika, L., Girardi, E. |
| بيانات النشر: | LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA |
| سنة النشر: | 2017 |
| المجموعة: | Università degli Studi di Genova: CINECA IRIS |
| مصطلحات موضوعية: | death, drug susceptibility testing, Eastern Europe, HIV, Latin America, TB: HIV study, treatment, tuberculosi, Western Europe |
| الوصف: | Objectives: The high mortality among HIV/tuberculosis (TB) coinfected patients in Eastern Europe is partly explained by the high prevalence of drug-resistant TB. It remains unclear whether outcomes of HIV/TB patients with rifampicin/isoniazid-susceptible TB in Eastern Europe differ from those in Western Europe or Latin America.Methods: One-year mortality of HIV-positive patients with rifampicin/isoniazidsusceptible TB in Eastern Europe, Western Europe, and Latin America was analysed and compared in a prospective observational cohort study. Factors associated with death were analysed using Cox regression modelsResults: Three hundred and forty-one patients were included (Eastern Europe 127, Western Europe 165, Latin America 49). Proportions of patients with disseminated TB (50, 58, 59%) and initiating rifampicin+isoniazid+pyrazinamide-based treatment (93, 94, 94%) were similar in Eastern Europe, Western Europe, and Latin America respectively, whereas receipt of antiretroviral therapy at baseline and after 12 months was lower in Eastern Europe (17, 39, 39%, and 69, 94, 89%). The 1-year probability of death was 16% (95% confidence interval 11-24%) in Eastern Europe, vs. 4% (2-9%) in Western Europe and 9% (3-21%) in Latin America; P< 0.0001. After adjustment for IDU, CD4(+) cell count and receipt of antiretroviral therapy, those residing in Eastern Europe were at nearly 3-fold increased risk of death compared with those in Western Europe/Latin America (aHR 2.79 (1.15-6.76); P=0.023).Conclusions: Despite comparable use of recommended anti-TB treatment, mortality of patients with rifampicin/isoniazid-susceptible TB remained higher in Eastern Europe when compared with Western Europe/Latin America. The high mortality in Eastern Europe was only partially explained by IDU, use of ART and CD4(+) cell count. These results call for improvement of care for TB/HIV patients in Eastern Europe. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000393753600009; volume:31; firstpage:375; lastpage:384; numberofpages:10; journal:AIDS; https://hdl.handle.net/11567/1155059; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85010041841 |
| DOI: | 10.1097/QAD.0000000000001333 |
| الاتاحة: | https://hdl.handle.net/11567/1155059 https://doi.org/10.1097/QAD.0000000000001333 |
| رقم الانضمام: | edsbas.C4A19887 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/QAD.0000000000001333 |
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