Dissertation/ Thesis
Printing technologies for personalization of dosage forms
| العنوان: | Printing technologies for personalization of dosage forms |
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| المؤلفون: | Öblom, Heidi |
| المساهمون: | Professor Clive Roberts, University of Nottingham, Nottingham, UK, Professor, docent Niklas Sandler, Åbo Akademi, Turku, Faculty of Science and Engineering, Fakulteten för naturvetenskaper och teknik, Luonnontieteiden ja tekniikan tiedekunta |
| بيانات النشر: | Åbo Akademi University |
| سنة النشر: | 2021 |
| المجموعة: | Doria (National Library of Finland / |
| مصطلحات موضوعية: | 317 Pharmacy, 317 Farmaci, 317 Farmasia, Pharmacy, Farmasi, Farmasia |
| الوصف: | Along with the recognized advantages of personalized medicine, a demand for new manufacturing technologies that allow for production of such products has emerged. Conventional pharmaceutical manufacturing techniques that have been used for production of dosage forms based on the ‘one-size-fits-all’ concept are not always suitable for manufacturing personalized dosage forms due to the lack of flexibility. Printing technologies have been explored for this purpose as their precise and flexible nature allows for on-demand printing of a limitless number of product designs with various personalization features, e.g., patient-tailored drug content, drug release profile, and customized functionality. In this thesis, three different printing technologies, i.e., fused deposition modeling (FDM), semisolid extrusion 3D printing (EXT), and inkjet printing (IJP), were used to prepare personalized solid dosage forms. Although all are printing techniques they require vastly different properties of the starting materials, involving solid, semisolid, and liquid states of matter. The starting materials prepared in this thesis were: drug-loaded filaments for FDM, drugloaded viscous dispersion for EXT, and drug-loaded ink solutions, as well as drug-free substrates for IJP. In the first study, FDM was utilized to print oral tablets with a personalized dose and tailored drug release of the model active pharmaceutical ingredient (API) isoniazid. This was achieved by modifying the digital design of tablets to be printed enabling printing of various-sized tablets with two different internal infill levels. In the second study, EXT and IJP were successfully used for production of orodispersible films (ODFs) containing 0.1-2 mg warfarin sodium (henceforward called warfarin). Regardless of the technique used to print warfarin, the desired dose was achieved by depositing the drug-containing feedstock material in a single layer. The printed ODFs were shown to have properties on par and even superior in some aspects compared to the oral powders ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | compositeOnly |
| اللغة: | English |
| ردمك: | 978-952-12-4132-1 978-952-12-4133-8 952-12-4132-2 952-12-4133-0 |
| Relation: | https://www.doria.fi/handle/10024/182601; URN:ISBN:978-952-12-4133-8 |
| الاتاحة: | https://www.doria.fi/handle/10024/182601 |
| Rights: | This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. ; Publikationen är skyddad av upphovsrätten. Den får läsas och skrivas ut för personligt bruk. Användning i kommersiellt syfte är förbjuden. ; Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. |
| رقم الانضمام: | edsbas.C481CCBB |
| قاعدة البيانات: | BASE |
| ردمك: | 9789521241321 9789521241338 9521241322 9521241330 |
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