Academic Journal
“All in one” nanoprobe Au-TTF-1 for target FL/CT bioimaging, machine learning technology and imaging-guided photothermal therapy against lung adenocarcinoma
| العنوان: | “All in one” nanoprobe Au-TTF-1 for target FL/CT bioimaging, machine learning technology and imaging-guided photothermal therapy against lung adenocarcinoma |
|---|---|
| المؤلفون: | Zhe Yang, Yujia Zhang, Lu Tang, Xiao Yang, Lei Song, Chun Shen, Andrei V. Zvyagin, Yang Li, Bai Yang, Quan Lin |
| المصدر: | Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-14 (2024) |
| بيانات النشر: | BMC |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Nanoprobe, Bioimaging-guided therapy, Machine learning, Dual-mode bioimaging, Lung adenocarcinoma, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | The accurate preoperative diagnosis and tracking of lung adenocarcinoma is hindered by non-targeting and diffusion of dyes used for marking tumors. Hence, there is an urgent need to develop a practical nanoprobe for tracing lung adenocarcinoma precisely even treating them noninvasively. Herein, Gold nanoclusters (AuNCs) conjugate with thyroid transcription factor-1 (TTF-1) antibody, then multifunctional nanoprobe Au-TTF-1 is designed and synthesized, which underscores the paramount importance of advancing the machine learning diagnosis and bioimaging-guided treatment of lung adenocarcinoma. Bright fluorescence (FL) and strong CT signal of Au-TTF-1 set the stage for tracking. Furthermore, the high specificity of TTF-1 antibody facilitates selective targeting of lung adenocarcinoma cells as compared to common lung epithelial cells, so machine learning software Lung adenocarcinoma auxiliary detection system was designed, which combined with Au-TTF-1 to assist the intelligent recognition of lung adenocarcinoma jointly. Besides, Au-TTF-1 not only contributes to intuitive and targeted visualization, but also guides the following noninvasive photothermal treatment. The boundaries of tumor are light up by Au-TTF-1 for navigation, it penetrates into tumor and implements noninvasive photothermal treatment, resulting in ablating tumors in vivo locally. Above all, Au-TTF-1 serves as a key platform for target bio-imaging navigation, machine learning diagnosis and synergistic PTT as a single nanoprobe, which demonstrates attractive performance on lung adenocarcinoma. Graphical Abstract |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1477-3155 |
| Relation: | https://doi.org/10.1186/s12951-023-02280-9; https://doaj.org/toc/1477-3155; https://doaj.org/article/8f9e0818ffaf43ceab8732a7dc3da4fa |
| DOI: | 10.1186/s12951-023-02280-9 |
| الاتاحة: | https://doi.org/10.1186/s12951-023-02280-9 https://doaj.org/article/8f9e0818ffaf43ceab8732a7dc3da4fa |
| رقم الانضمام: | edsbas.C4580798 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14773155 |
|---|---|
| DOI: | 10.1186/s12951-023-02280-9 |