Academic Journal
Codon Bias Can Determine Sorting of a Potassium Channel Protein
| العنوان: | Codon Bias Can Determine Sorting of a Potassium Channel Protein |
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| المؤلفون: | Engel, Anja J., Kithil, Marina, Langhans, Markus, Rauh, Oliver, Cartolano, Matea, Etten, James L. Van, Moroni, Anna, Thiel, Gerhard |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| المجموعة: | TU Darmstadt: tuprints |
| الوصف: | Due to the redundancy of the genetic code most amino acids are encoded by multiple synonymous codons. It has been proposed that a biased frequency of synonymous codons can affect the function of proteins by modulating distinct steps in transcription, translation and folding. Here, we use two similar prototype K+ channels as model systems to examine whether codon choice has an impact on protein sorting. By monitoring transient expression of GFP-tagged channels in mammalian cells, we find that one of the two channels is sorted in a codon and cell cycle-dependent manner either to mitochondria or the secretory pathway. The data establish that a gene with either rare or frequent codons serves, together with a cell-state-dependent decoding mechanism, as a secondary code for sorting intracellular membrane proteins. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://tuprints.ulb.tu-darmstadt.de/19352/1/cells-10-01128%20%281%29.pdf; Engel, Anja J.; Kithil, Marina; Langhans, Markus; Rauh, Oliver; Cartolano, Matea; Etten, James L. Van; Moroni, Anna; Thiel, Gerhard (2021)Codon Bias Can Determine Sorting of a Potassium Channel Protein. In: Cells, 2021, 10 (5) doi:10.26083/tuprints-00019352 Article, Secondary publication, Publisher's Version |
| DOI: | 10.26083/tuprints-00019352 |
| الاتاحة: | http://tuprints.ulb.tu-darmstadt.de/19352/ https://tuprints.ulb.tu-darmstadt.de/19352/1/cells-10-01128%20%281%29.pdf https://doi.org/10.26083/tuprints-00019352 |
| Rights: | CC BY 4.0 International - Creative Commons, Attribution ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C41BEFE0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.26083/tuprints-00019352 |
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