Academic Journal
Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies
| العنوان: | Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies |
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| المؤلفون: | Bhattacharjee, Rahul, Das, Sabya Sachi, Biswal, Smruti Sudha, Nath, Arijit, Das, Debangshi, Basu, Asmita, Malik, Sumira, Kumar, Lamha, Kar, Sulagna, Singh, Sandeep Kumar, Upadhye, Vijay Jagdish, Iqbal, Danish, Almojam, Suliman, Roychoudhury, Shubhadeep, Ojha, Shreesh, Ruokolainen, Janne, Jha, Niraj Kumar, Kesari, Kavindra Kumar |
| المساهمون: | Department of Applied Physics, Department of Bioproducts and Biosystems, Molecular Materials, Wood Chemistry, Kalinga Institute of Industrial Technology, Birla Institute of Technology, Mesra, National Institute of Technology, Rourkela, West Bengal University of Technology, Amity University, Indian Institute of Science Education and Research Thiruvananthapuram, Parul Institute of Applied Sciences, Majmaah University, Ministry of Health, Saudi Arabia, Assam University, United Arab Emirates University, Sharda University, Aalto-yliopisto, Aalto University |
| بيانات النشر: | Elsevier Ireland Ltd |
| سنة النشر: | 2022 |
| المجموعة: | Aalto University Publication Archive (Aaltodoc) / Aalto-yliopiston julkaisuarkistoa |
| مصطلحات موضوعية: | Cervical cancer, E proteins, HPV, Molecular mechanisms, Signaling pathways, Therapeutic targets |
| الوصف: | Funding Information: Dr. Niraj Kumar Jha is thankful to Sharda University for the infrastructure and facility. The author would like to thank Deanship of Scientific Research at Majmaah University for supporting this work under project number No. R-2022-68 . Kavindra Kumar Kesari and Janne Ruokolainen thanking Aalto University for providing open access support. The authors would like to acknowledge the support from their respective institutes throughout the review writing process. ; Purpose: Cervical cancer (CC), one of the major causes of death of women throughout the world is primarily caused due to Human Papilloma Virus (HPV) 16 and 18. The early region (E) oncoproteins of HPV are associated with the etiopathogenesis and contribute to the progression of cancer. The present article comprehensively discussed the structural organization and biological functions of all E proteins of HPV and their contribution to progression of CC with an intent to decipher the pathological hallmarks and their relationship. Additionally, the role of E proteins in reference to therapeutics will also be presented. Methods: A systematic search has been carried out for articles published in PubMed database by using combinations of different keywords with Boolean operators (AND, OR, NOT) including cervical cancer, HPV, E proteins, and signaling. Results: From the analysis of literature review, its apparent that E proteins are the major contributor to disease progression. E1, E2, and E4 forms are mainly associated with viral integration, replication, and transcription whereas E6 and E7 act as an oncoprotein and are associated with the progression of cancer. E5 regulates cell proliferation, apoptosis, and facilitates the activity of E6 and E7. Additionally, E proteins were observed associated with numerous cell signaling pathways including PI3K/AKT, Wnt, Notch and reasonably contribute to the initiation of malignancy, cell proliferation, metastasis, and drug resistance. Knowing the role and interplay of each protein in initiation to ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1-17; application/pdf |
| اللغة: | English |
| تدمد: | 1040-8428 1879-0461 |
| Relation: | Critical Reviews in Oncology/Hematology; Volume 174; Bhattacharjee, R, Das, S S, Biswal, S S, Nath, A, Das, D, Basu, A, Malik, S, Kumar, L, Kar, S, Singh, S K, Upadhye, V J, Iqbal, D, Almojam, S, Roychoudhury, S, Ojha, S, Ruokolainen, J, Jha, N K & Kesari, K K 2022, ' Mechanistic role of HPV-associated early proteins in cervical cancer : Molecular pathways and targeted therapeutic strategies ', Critical Reviews in Oncology/Hematology, vol. 174, 103675, pp. 1-17 . https://doi.org/10.1016/j.critrevonc.2022.103675; PURE UUID: 933fbeea-8b6b-44a2-856c-d6941b3ece85; PURE ITEMURL: https://research.aalto.fi/en/publications/933fbeea-8b6b-44a2-856c-d6941b3ece85; PURE LINK: http://www.scopus.com/inward/record.url?scp=85129648484&partnerID=8YFLogxK; PURE FILEURL: https://research.aalto.fi/files/83365878/Mechanistic_role_of_HPV_associated_early_proteins_in_cervical_cancer.pdf; https://aaltodoc.aalto.fi/handle/123456789/114551; URN:NBN:fi:aalto-202205243398 |
| DOI: | 10.1016/j.critrevonc.2022.103675 |
| الاتاحة: | https://aaltodoc.aalto.fi/handle/123456789/114551 https://doi.org/10.1016/j.critrevonc.2022.103675 |
| Rights: | openAccess |
| رقم الانضمام: | edsbas.C416E851 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10408428 18790461 |
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| DOI: | 10.1016/j.critrevonc.2022.103675 |