Academic Journal
APOE Genotype and Entorhinal Cortex Volume in Non-Demented Community-Dwelling Adults in Midlife and
| العنوان: | APOE Genotype and Entorhinal Cortex Volume in Non-Demented Community-Dwelling Adults in Midlife and |
|---|---|
| المؤلفون: | Early Old Age, David Bunce A, Kaarin J. Anstey B, Nicolas Cherbuin B, Prapti Gautam B, Perminder Sachdev C, Simon Easteal E |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://bura.brunel.ac.uk/bitstream/2438/7223/2/Fulltext.pdf. |
| سنة النشر: | 2012 |
| المجموعة: | CiteSeerX |
| مصطلحات موضوعية: | Age, Alzheimer’s disease, APOE, entorhinal cortex |
| الوصف: | The apolipoprotein E (APOE) ε4 allele is a risk factor for the neuropathological decline accompanying Alzheimer’s disease (AD) while, conversely, the ε2 allele offers protection. One of the brain structures exhibiting the earliest changes associated with the disease is the entorhinal cortex. We therefore investigated the volumes of the entorhinal cortex and other structures in the medial temporal lobe including the parahippocampal gyrus, temporal pole, and inferior, middle, and superior temporal cortices, in relation to APOE genotype. Our main objectives were to determine if (a) volumes systematically varied according to allele in a stepwise fashion, ε2>ε3>ε4, and (b) associations varied according to age. We investigate this association in 627 non-demented community-dwelling adults in middle age (44 to 48 years; n = 314) and older age (64 to 68 years; n = 313) who underwent structural MRI scans. We found no evidence of APOE-related variation in brain volumes in the age groups examined. We conclude that if a ε2>ε3>ε4 pattern in brain volumes does emerge in non-demented adults living in the community in old age, it is not until after the age of 68 years. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.425.2313; http://bura.brunel.ac.uk/bitstream/2438/7223/2/Fulltext.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.425.2313 http://bura.brunel.ac.uk/bitstream/2438/7223/2/Fulltext.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.C40170AF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |