التفاصيل البيبلوغرافية
| العنوان: |
TiO 2 Nanotubes Alginate Hydrogel Scaffold for Rapid Sensing of Sweat Biomarkers: Lactate and Glucose |
| المؤلفون: |
Udara Bimendra Gunatilake (11219481), Sandra Garcia-Rey (11219484), Edilberto Ojeda (11219487), Lourdes Basabe-Desmonts (1729972), Fernando Benito-Lopez (1988449) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Medicine, Biotechnology, Computational Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sweat components, colorimetric detection, wearable devices, sweat biomarkers, cellulose paper, sensor scaffold, matrixe, paper-based sensor devices, 6 min, Rapid colorimetric detection, titanium dioxide nanotubes, scaffold platform, cross-linking nanocomposite, signal readout behavior, hydrogel, detection times, paper substrate, Glucose Versatile, lactate, alginate matrix, dicationic calcium ions, TiO 2 Nanotubes Alginate Hydrogel S., image analysis, glucose biomarkers |
| الوصف: |
Versatile sensing matrixes are essential for the development of enzyme-immobilized optical biosensors. A novel three-dimensional titanium dioxide nanotubes/alginate hydrogel scaffold is proposed for the detection of sweat biomarkers, lactate, and glucose in artificial sweat. Hydrothermally synthesized titanium dioxide nanotubes were introduced to the alginate polymeric matrix, followed by cross-linking nanocomposite with dicationic calcium ions to fabricate the scaffold platform. Rapid colorimetric detection (blue color optical signal) was carried out for both lactate and glucose biomarkers in artificial sweat at 4 and 6 min, respectively. The superhydrophilicity and the capillarity of the synthesized titanium dioxide nanotubes, when incorporated into the alginate matrix, facilitate the rapid transfer of the artificial sweat components throughout the sensor scaffold, decreasing the detection times. Moreover, the scaffold was integrated on a cellulose paper to demonstrate the adaptability of the material to other matrixes, obtaining fast and homogeneous colorimetric detection of lactate and glucose in the paper substrate when image analysis was performed. The properties of this new composite provide new avenues in the development of paper-based sensor devices. The biocompatibility, the efficient immobilization of biological enzymes/colorimetric assays, and the quick optical signal readout behavior of the titanium dioxide nanotubes/alginate hydrogel scaffolds provide a prospective opportunity for integration into wearable devices. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/TiO_sub_2_sub_Nanotubes_Alginate_Hydrogel_Scaffold_for_Rapid_Sensing_of_Sweat_Biomarkers_Lactate_and_Glucose/15094485 |
| DOI: |
10.1021/acsami.1c11446.s001 |
| الاتاحة: |
https://doi.org/10.1021/acsami.1c11446.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.C3E08E9C |
| قاعدة البيانات: |
BASE |