Academic Journal
Analgesic tolerance and cross-tolerance to i.c.v. endomorphin-1, endomorphin-2, and morphine in mice; 15276249
| العنوان: | Analgesic tolerance and cross-tolerance to i.c.v. endomorphin-1, endomorphin-2, and morphine in mice; 15276249 |
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| المؤلفون: | Soignier, R. D., Vaccarino, A. L., Fanti, Kostas A., Wilson, A. M., Zadina, J. E. |
| المساهمون: | Fanti, Kostas A. 0000-0002-3484-7483 |
| المصدر: | Neuroscience letters ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-3242798948&doi=10.1016%2fj.neulet.2004.05.046&partnerID=40&md5=6641b8a17d3e530d7613cf883776efd8 ; Neurosci.Lett. |
| سنة النشر: | 2004 |
| المجموعة: | University of Cyprus: Gnosis Institutional Repository / Ιδρυματικό αποθετήριο Πανεπιστημίου Κύπρου "Γνῶσις" |
| مصطلحات موضوعية: | Analgesia, Antinociception, Hot-plate, Opioid, Pain, Peptides, Analgesic agent, Drug vehicle, Endomorphin 1, Endomorphin 2, Morphine, Mu opiate receptor, Anesthesia mechanism, Animal experiment, Article, Controlled study, Drug cross tolerance, Drug screening, Drug tolerance, Male, Mouse, Nonhuman, Observation, Priority journal, Time, Analgesics, Animals, Injections, intraventricular, Mice |
| الوصف: | The present study examined the development of analgesic tolerance to endomorphin-1 (EM1), endomorphin-2 (EM2), and morphine, and cross-tolerance among these drugs. Male Swiss Webster mice were injected i.c.v. with EM1, EM2, morphine, or vehicle once daily for 5 days, and tested for analgesia in the tail flick test. To determine the extent of cross-tolerance, on the sixth day mice from each of the above groups received i.c.v. injections of EM1, EM2, morphine, or vehicle before analgesic testing. The development of tolerance to EM1 and EM2 closely resembled that of morphine. Complete, symmetrical cross-tolerance was observed between all drugs in the study. These results demonstrate a time-course and extent of tolerance similar to morphine, and support a common mechanism of action through the mu-opioid receptor. © 2004 Published by Elsevier Ireland Ltd. ; 366 ; 2 ; 211 ; 214 ; J2: Neurosci. Lett.; Cited By :9; Export Date: 12 July 2017; CODEN: NELED; Correspondence Address: Soignier, R.D.; Louisiana State University, School of Medicine, 533 Bolivar St., Room 324, 70112, New Orleans, LA, United States; email: rsoign@lsuhsc.edu |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | 03043940 (ISSN); https://gnosis.library.ucy.ac.cy/handle/7/37629 |
| DOI: | 10.1016/j.neulet.2004.05.046 |
| الاتاحة: | https://gnosis.library.ucy.ac.cy/handle/7/37629 https://doi.org/10.1016/j.neulet.2004.05.046 |
| رقم الانضمام: | edsbas.C365B299 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.neulet.2004.05.046 |
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