التفاصيل البيبلوغرافية
| العنوان: |
Improving the Photodynamic Activity of Water‐Soluble Porphyrin–Polysaccharide Complexes by Folic Acid Modification |
| المؤلفون: |
Nishimura, Kotaro, Kono, Nanami, Oshige, Ayano, Takahashi, Haruko, Yamana, Keita, Kawasaki, Riku, Ikeda, Atsushi |
| المصدر: |
ChemMedChem ; volume 19, issue 20 ; ISSN 1860-7179 1860-7187 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Studies have shown that folate receptors are highly expressed in various cancer cells. Here, we synthesized folic acid‐conjugated pullulan (FAPL) as a solubilizing agent to improve the photodynamic activity of porphyrin derivative–polysaccharide complexes. The porphyrin derivative–FAPL complex exhibited long‐term stability in an aqueous solution, attributed to the folic acid modification. Furthermore, in vitro and in vivo experiments highlighted the enhanced photodynamic activity of the porphyrin derivative–FAPL complex toward 4T1 breast‐cancer cells, compared with the activities of the porphyrin derivative–pullulan complex and Photofrin. This enhanced activity is attributed to the improvement of intracellular uptake by the folate receptor. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/cmdc.202400268 |
| الاتاحة: |
https://doi.org/10.1002/cmdc.202400268 |
| Rights: |
http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: |
edsbas.C3533C22 |
| قاعدة البيانات: |
BASE |