التفاصيل البيبلوغرافية
| العنوان: |
Serum AMH levels in healthy women from BRCA1/2 mutated families: are they reduced? |
| المؤلفون: |
van Tilborg, Theodora C, Derks-Smeets, Inge A P, Bos, Anna M E, Oosterwijk, Jan C, van Golde, Ron J, de Die-Smulders, Christine E, van der Kolk, Lizet E, van Zelst-Stams, Wendy A G, Velthuizen, Maria E, Hoek, Annemieke, Eijkemans, Marinus J C, Laven, Joop S E, Ausems, Margreet G E M, Broekmans, Frank J M |
| المساهمون: |
MS VPG/Gynaecologie, Cancer, Child Health, Genetica, Biostatistiek Onderzoek, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Genetica Sectie Oncogenetica |
| سنة النشر: |
2016 |
| مصطلحات موضوعية: |
Journal Article |
| الوصف: |
STUDY QUESTION: Do BRCA1/2 mutation carriers have a compromised ovarian reserve compared to proven non-carriers, based on serum anti-Müllerian hormone (AMH) levels? SUMMARY ANSWER: BRCA1/2 mutation carriers do not show a lower serum AMH level in comparison to proven non-carriers, after adjustment for potential confounders. WHAT IS KNOWN ALREADY: It has been suggested that the BRCA genes play a role in the process of ovarian reserve depletion, although previous studies have shown inconsistent results regarding the association between serum AMH levels and BRCA mutation status. Hence, it is yet unclear whether BRCA1/2 mutation carriers may indeed be at risk of a reduced reproductive lifespan. STUDY DESIGN, SIZE, DURATION: A multicenter, cross-sectional study was performed between January 2012 and February 2015 in 255 women. We needed to include 120 BRCA1/2 mutation carriers and 120 proven non-carriers to demonstrate a difference in AMH levels of 0.40 µg/l (SD ± 0.12 µg/l, two-sided alpha-error 0.05, power 80%). PARTICIPANTS/MATERIALS, SETTING, METHOD: Healthy women aged 18-45 years who were referred to the Clinical Genetics Department and applied for predictive BRCA1/2 testing because of a familial BRCA1/2 mutation were asked to participate. A cross-sectional assessment was performed by measuring serum AMH levels and filling out a questionnaire. Multivariate linear regression analyses adjusted for age, current smoking and current hormonal contraceptive use were performed on log-transformed serum AMH levels. MAIN RESULTS AND THE ROLE OF CHANCE: Out of 823 potentially eligible women, 421 (51.2%) were willing to participate, and of those, 166 (39%) did not meet our inclusion criteria. Two hundred and fifty-five women were available for analyses; 124 BRCA1/2 mutation carriers and 131 proven non-carriers. The median [range] AMH level in carriers was 1.90 µg/l [0.11-19.00] compared to 1.80 µg/l [0.11-10.00] in non-carriers (P = 0.34). Adjusted linear regression analysis revealed no reduction in AMH level in the carriers ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0268-1161 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/343404 |
| الاتاحة: |
https://dspace.library.uu.nl/handle/1874/343404 |
| Rights: |
info:eu-repo/semantics/ClosedAccess |
| رقم الانضمام: |
edsbas.C31D3931 |
| قاعدة البيانات: |
BASE |
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