Academic Journal
Differential MHC class II component expression in HPV‐positive cervical cancer cells: Implication for immune surveillance
| العنوان: | Differential MHC class II component expression in HPV‐positive cervical cancer cells: Implication for immune surveillance |
|---|---|
| المؤلفون: | Zehbe, Ingeborg, Höhn, Hanni, Pilch, Henryk, Neukirch, Claudia, Freitag, Kirsten, Maeurer, Markus J. |
| المصدر: | International Journal of Cancer ; volume 117, issue 5, page 807-815 ; ISSN 0020-7136 1097-0215 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2005 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Effective eradication of human papillomavirus (HPV)‐positive tumors may require CD8+ and CD4+ T‐cell‐mediated immune responses. Ectopic expression of MHC class II surface molecules has been described in the context of cervical cancer, but coexpression with other components of the MHC class II antigen presentation pathway has not been addressed. We have evaluated the MHC class II antigen presentation pathway in malignant squamous epithelium of HPV+ cervical cancer lesions by in situ costaining HLA‐DR with CLIP or DMA/DMB. Cervical cancer cells exhibit 3 MHC class II phenotypes: ( i ) DR+/CLIP+ or DM+; ( ii ) DR+/CLIP‐ or DM‐; and ( iii ) DR‐/CLIP+ or DM+. The identical profile has been identified in HPV+ ME180 cells, which serve as a target for HLA‐DR4‐restricted and HPV68, E7‐specific CD4+ T cells. IFN‐γ pretreatment of ME180 cells, associated with differential trafficking of MHC class II molecules, is necessary for effective T‐cell recognition. Although proinflammatory cytokines may facilitate MHC class II‐restricted antigen recognition in tumor cells, different phenotypes of the MHC class II antigen presentation pathway may be associated with evasion from CD4+‐mediated cellular immune responses. © 2005 Wiley‐Liss, Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/ijc.21226 |
| الاتاحة: | http://dx.doi.org/10.1002/ijc.21226 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.21226 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.21226 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.C3079003 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ijc.21226 |
|---|