Academic Journal
Characterization and Pharmacokinetic Evaluation of Oxaliplatin Long-Circulating Liposomes
| العنوان: | Characterization and Pharmacokinetic Evaluation of Oxaliplatin Long-Circulating Liposomes |
|---|---|
| المؤلفون: | Nihad Cheraga, Ammar Ouahab, Yan Shen, Ning-Ping Huang |
| المصدر: | BioMed Research International, Vol 2021 (2021) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine |
| الوصف: | The clinical efficacy of Oxaliplatin (L-OHP) is potentially limited by dose-dependent neurotoxicity and high partitioning to erythrocytes in vivo. Long-circulating liposomes could improve the pharmacokinetic profile of L-OHP and thus enhance its therapeutic efficacy and reduce its toxicity. The purpose of this study was to prepare L-OHP long-circulating liposomes (L-OHP PEG lip) by reverse-phase evaporation method (REV) and investigate their pharmacokinetic behavior based on total platinum in rat plasma using atomic absorption spectrometry (AAS). A simple and a sensitive AAS method was developed and validated to determine the total platinum originated from L-OHP liposomes in plasma. Furthermore, long-circulating liposomes were fully characterized in vitro and showed great stability when stored at 4°C for one month. The results showed that the total platinum in plasma of L-OHP long-circulating liposomes displayed a biexponential pharmacokinetic profile with five folds higher bioavailability and longer distribution half-life compared to L-OHP solution. Thus, long-circulating liposomes prolonged L-OHP circulation time and may present a potential candidate for its tumor delivery. Conclusively, the developed AAS method could serve as a reference to investigate the pharmacokinetic behavior of total platinum in biological matrices for other L-OHP delivery systems. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2314-6133 2314-6141 |
| Relation: | http://dx.doi.org/10.1155/2021/5949804; https://doaj.org/toc/2314-6133; https://doaj.org/toc/2314-6141; https://doaj.org/article/19464283852e4cfeb0aa021121d57c7c |
| DOI: | 10.1155/2021/5949804 |
| الاتاحة: | https://doi.org/10.1155/2021/5949804 https://doaj.org/article/19464283852e4cfeb0aa021121d57c7c |
| رقم الانضمام: | edsbas.C3035863 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23146133 23146141 |
|---|---|
| DOI: | 10.1155/2021/5949804 |