التفاصيل البيبلوغرافية
| العنوان: |
β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure |
| المؤلفون: |
Siddhartha Banerjee, Divya Baghel, Ana Pacheco de Oliveira, Ayanjeet Ghosh |
| المصدر: |
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5175 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
β-carotene, amyloid aggregation, AFM-IR, fibril structure, beta-sheet |
| جغرافية الموضوع: |
agris |
| الوصف: |
The aggregation of amyloid beta (Aβ) into fibrillar aggregates is a key feature of Alzheimer’s disease (AD) pathology. β-carotene and related compounds have been shown to associate with amyloid aggregates and have direct impact on the formation of amyloid fibrils. However, the precise effect of β-carotene on the structure of amyloid aggregates is not known, which poses a limitation towards developing it as a potential AD therapeutic. In this report, we use nanoscale AFM-IR spectroscopy to probe the structure of Aβ oligomers and fibrils at the single aggregate level and demonstrate that the main effect of β-carotene towards modulating Aβ aggregation is not to inhibit fibril formation but to alter the secondary structure of the fibrils and promote fibrils that lack the characteristic ordered beta structure. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Macromolecules; https://dx.doi.org/10.3390/ijms24065175 |
| DOI: |
10.3390/ijms24065175 |
| الاتاحة: |
https://doi.org/10.3390/ijms24065175 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.C2FE71D9 |
| قاعدة البيانات: |
BASE |