التفاصيل البيبلوغرافية
| العنوان: |
Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice |
| المؤلفون: |
Palak Ahuja (11602697), Chun Fai Ng (11602700), Brian Pak Shing Pang (11602703), Wing Suen Chan (11602706), Margaret Chui Ling Tse (11602709), Xinyi Bi (11602712), Hiu-Lam Rachel Kwan (11602715), Daniel Brobst (11602718), Oana Herlea-Pana (11522686), Xiuying Yang (5201399), Guanhua Du (620091), Suchaorn Saengnipanthkul (11602721), Hye Lim Noh (9299300), Baowei Jiao (5369540), Jason K. Kim (9299304), Chi Wai Lee (11602724), Keqiang Ye (9444), Chi Bun Chan (8377266) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Evolutionary Biology, Computational Biology, Cardiology, Chemical Sciences not elsewhere classified, BDNF, mitochondria, mitophagy, muscle, obesity |
| الوصف: |
Mitochondrial remodeling is dysregulated in metabolic diseases but the underlying mechanism is not fully understood. We report here that BDNF (brain derived neurotrophic factor) provokes mitochondrial fission and clearance in skeletal muscle via the PRKAA/AMPK-PINK1-PRKN/Parkin and PRKAA-DNM1L/DRP1-MFF pathways. Depleting Bdnf expression in myotubes reduced fatty acid-induced mitofission and mitophagy, which was associated with mitochondrial elongation and impaired lipid handling. Muscle-specific bdnf knockout (MBKO) mice displayed defective mitofission and mitophagy, and accumulation of dysfunctional mitochondria in the muscle when they were fed with a high-fat diet (HFD). These animals also have exacerbated body weight gain, increased intramyocellular lipid deposition, reduced energy expenditure, poor metabolic flexibility, and more insulin resistance. In contrast, consuming a BDNF mimetic (7,8-dihydroxyflavone) increased mitochondrial content, and enhanced mitofission and mitophagy in the skeletal muscles. Hence, BDNF is an essential myokine to maintain mitochondrial quality and function, and its repression in obesity might contribute to impaired metabolism. Abbreviation: 7,8-DHF: 7,8-dihydroxyflavone; ACACA/ACC: acetyl Coenzyme A carboxylase alpha; ACAD: acyl-Coenzyme A dehydrogenase family; ACADVL: acyl-Coenzyme A dehydrogenase, very long chain; ACOT: acyl-CoA thioesterase; CAMKK2: calcium/calmodulin-dependent protein kinase kinase 2, beta; BDNF: brain derived neurotrophic factor; BNIP3: BCL2/adenovirus E1B interacting protein 3; BNIP3L/NIX: BCL2/adenovirus E1B interacting protein 3-like; CCL2/MCP-1: chemokine (C-C motif) ligand 2; CCL5: chemokine (C-C motif) ligand 5; CNS: central nervous system; CPT1B: carnitine palmitoyltransferase 1b, muscle; Cpt2: carnitine palmitoyltransferase 2; CREB: cAMP responsive element binding protein; DNM1L/DRP1: dynamin 1-like; E2: estrogen; EHHADH: enoyl-CoenzymeA hydratase/3-hydroxyacyl CoenzymeA dehydrogenase; ESR1/ER-alpha: estrogen receptor 1 (alpha); FA: fatty acid; ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Muscle-generated_BDNF_brain_derived_neurotrophic_factor_maintains_mitochondrial_quality_control_in_female_mice/16866293 |
| DOI: |
10.6084/m9.figshare.16866293.v1 |
| الاتاحة: |
https://doi.org/10.6084/m9.figshare.16866293.v1 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.C2F7A1F0 |
| قاعدة البيانات: |
BASE |