Academic Journal
Electronic sanitary database: a new potential tool to identify occult chronic liver disease in general population
| العنوان: | Electronic sanitary database: a new potential tool to identify occult chronic liver disease in general population |
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| المؤلفون: | Cagnin, Silvia, Martini, Andrea, Donato, Daniele, Angeli, Paolo, Pontisso, Patrizia |
| المساهمون: | Cagnin, Silvia, Martini, Andrea, Donato, Daniele, Angeli, Paolo, Pontisso, Patrizia |
| بيانات النشر: | Springer Science and Business Media Deutschland GmbH |
| سنة النشر: | 2024 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Chronic liver disease, Cirrhosi, Early diagnosi, Epidemiology |
| الوصف: | Chronic liver disease (CLD) is a leading global cause of mortality, morbidity, and healthcare resource utilization. However, the burden of CLD is underestimated because the course of the disease is often asymptomatic until clinical decompensation and the development of life-threatening complications. In this study, we assessed the use of available blood tests from electronic medical records for identifying individuals with undiagnosed CLD in the general population. We analyzed a total of 202,529 blood tests obtained from 99,848 adults recorded in the Electronic Health Records of the Padova Teaching Hospital. Transaminases levels > 1.5 times the normal value indicated occult CLD, while platelet counts < 120,000/μL identified occult cirrhosis. We characterized patients using Italian Medical Exemptions (IME), excluding oncologic cases. Overt and occult cirrhosis prevalence was 1% and 4.18%, respectively, while overt and occult CLD affected 2.85% and 4.61% of the population. The epidemiology of patients with overt and occult cirrhosis was similar but significantly different from that of the controls. Among subjects aged 60–70 years, working disability was twofold higher in those with occult cirrhosis compared to those with overt cirrhosis. Occult CLD and cirrhosis had higher prevalence rates than diagnosed cases in the general population. Electronic medical record data may serve as a valuable tool for CLD identification, potentially reducing cirrhosis development and clinical decompensation. This, in turn, may lead to a decrease in the economic impact on the healthcare system. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38227274; info:eu-repo/semantics/altIdentifier/wos/WOS:001154296100002; journal:INTERNAL AND EMERGENCY MEDICINE; https://hdl.handle.net/11577/3504014; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85182474185 |
| DOI: | 10.1007/s11739-023-03507-1 |
| الاتاحة: | https://hdl.handle.net/11577/3504014 https://doi.org/10.1007/s11739-023-03507-1 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C2CA4A03 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s11739-023-03507-1 |
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