Academic Journal
Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis
| العنوان: | Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis |
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| المؤلفون: | Tournadre, Anne, Pereira, Bruno, Dutheil, Fréderic, Giraud, Charlotte, Courteix, Daniel, Sapin, Vincent, Frayssac, Thomas, Mathieu, Sylvain, Malochet-Guinamand, Sandrine, Soubrier, Martin |
| المساهمون: | Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne 2017-2020 (UCA 2017-2020 ), Université Clermont Auvergne 2017-2020 (UCA 2017-2020 ), Rhumatologie, Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS)-Les Hôpitaux Universitaires de Strasbourg (HUS), Biostatistique, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Clermont-Ferrand, Santé Travail Environnement, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne 2017-2020 (UCA 2017-2020 )-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne 2017-2020 (UCA 2017-2020 )-Université Clermont Auvergne 2017-2020 (UCA 2017-2020 ), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Université Clermont Auvergne 2017-2020 (UCA 2017-2020 )-Centre National de la Recherche Scientifique (CNRS), Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Centre National de la Recherche Scientifique (CNRS), Australian Catholic University (ACU), Biochimie-Biologie Moléculaire, Retinoids, Development and Developmental Diseases (R2D2), Université d'Auvergne - Clermont-Ferrand I (UdA) |
| المصدر: | ISSN: 2190-5991. |
| بيانات النشر: | HAL CCSD Wiley Open Access/Springer Verlag |
| سنة النشر: | 2017 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | Cachexia, Metabolic change, Rheumatoid arthritis, Sarcopaenia, Tocilizumab, clinical study, cardiovascular disease, désordre métabolique, Polyarthrite rhumatoïde, étude clinique, maladie cardiovasculaire, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | This study was funded by Roche Chugai; Pfizer; AbbVie; Union Chimique Belge Pharma; Merck Sharp and Dohme (MSD) ; BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by increased mortality associated with cardiometabolic disorders including dyslipidaemia, insulin resistance, and cachectic obesity. Tumour necrosis factor inhibitors and interleukin 6 receptor blocker licensed for the treatment of RA decrease inflammation and could thus improve cardiovascular risk, but their effects on body composition and metabolic profile need to be clarified. We investigated the effects of tocilizumab (TCZ), a humanized anti-interleukin 6 receptor antibody, on body composition and metabolic profile in patients treated for RA. METHODS: Twenty-one active RA patients treated with TCZ were included in a 1 year open follow-up study. Waist circumference, body mass index, blood pressure, lipid profile, fasting glucose, insulin, serum levels of adipokines and pancreatic/gastrointestinal hormones, and body composition (dual-energy X-ray absorptiometry) were measured at baseline and 6 and 12 months of treatment. At baseline, RA patients were compared with 21 non-RA controls matched for age, sex, body mass index, and metabolic syndrome. RESULTS: Compared with controls, body composition was altered in RA with a decrease in total and appendicular lean mass, whereas fat composition was not modified. Among RA patients, 28.6% had a skeletal muscle mass index below the cut-off point for sarcopaenia (4.8% of controls). After 1 year of treatment with TCZ, there was a significant weight gain without changes for fat mass. In contrast, an increase in lean mass was observed with a significant gain in appendicular lean mass and skeletal muscle mass index between 6 and 12 months. Distribution of the fat was modified with a decrease in trunk/peripheral fat ratio and an increase in subcutaneous adipose tissue. No changes for waist circumference, blood pressure, fasting glucose, and atherogenic index were observed. ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/28316139; hal-01595449; https://hal.science/hal-01595449; https://hal.science/hal-01595449/document; https://hal.science/hal-01595449/file/2017_Tournadre_Change%20in%20body_J%20Cachexia%20Sarcopenia%20Muscle_%7BEC09C9E8-7EBE-4CAF-AB20-DBC0E875BB12%7D.pdf; PRODINRA: 390353; PUBMED: 28316139; WOS: 000408191800014 |
| DOI: | 10.1002/jcsm.12189 |
| الاتاحة: | https://hal.science/hal-01595449 https://hal.science/hal-01595449/document https://hal.science/hal-01595449/file/2017_Tournadre_Change%20in%20body_J%20Cachexia%20Sarcopenia%20Muscle_%7BEC09C9E8-7EBE-4CAF-AB20-DBC0E875BB12%7D.pdf https://doi.org/10.1002/jcsm.12189 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.C2BB9439 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jcsm.12189 |
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