Academic Journal
Circulating amyloidogenic free light chains and serum N-terminal natriuretic peptide type B decrease simultaneously in association with improvement of survival in AL amyloidosis
| العنوان: | Circulating amyloidogenic free light chains and serum N-terminal natriuretic peptide type B decrease simultaneously in association with improvement of survival in AL amyloidosis |
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| المؤلفون: | G. Palladini, F. Lavatelli, P. Russo, S. Perlini, T. Bosoni, L. Obici, A. R. Bradwell, R. Fogari, R. Moratti, G. Merlini, G.V. Melzi d’Eril |
| المساهمون: | G. Palladini, F. Lavatelli, P. Russo, S. Perlini, T. Bosoni, L. Obici, A.R. Bradwell, G.V. Melzi d’Eril, R. Fogari, R. Moratti, G. Merlini |
| بيانات النشر: | W.B.Saunders |
| سنة النشر: | 2006 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica |
| الوصف: | N-terminal natriuretic peptide type B (NT-proBNP) is a marker of cardiac dysfunction in light chain amyloidlosis (AL) and a powerful prognostic determinant. Serum NT-proBNP and circulating free light chains (FLCs) were measured at enrollment and after 3 cycles of chemotherapy in 51 patients with cardiac AL. In patients (n = 22, 43%) in whom FLCs decreased by more than 50% (hematologic response), NT-proBNP concentration decreased by a median of 48%, whereas in the remaining patients it increased by 47% (P = .01). The reduction of NT-proBNP was greater in patients (n = 9) in whom amyloidogenic FLCs disappeared at immunofixation (median 53%), than in the remaining responding patients (median 31%, P = .04). Left ventricular wall thickness decreased by at least 2 mm in 3 of 20 patients in whom NT-proBNP improved. Fifteen patients died. Thirteen of them, in whom NT-proBNP and FLCs did not improve, died after a median of 1.8 months. The decrease of FLCs translates into a simultaneous decrease of NT-proBNP and improved survival. Patients in whom chemotherapy fails to induce such a decrease are at risk of early death. Cardiac function in AL can rapidly improve due to a reduction of the circulating amyloidogenic precursor, despite the amount of cardiac amyloid deposits remaining apparently unaltered, as measured by echocardiography. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/16434487; info:eu-repo/semantics/altIdentifier/wos/WOS:000237584500015; volume:107; issue:10; firstpage:3854; lastpage:3858; journal:BLOOD; http://hdl.handle.net/2434/5032; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33646597285 |
| DOI: | 10.1182/blood-2005-11-4385 |
| الاتاحة: | http://hdl.handle.net/2434/5032 https://doi.org/10.1182/blood-2005-11-4385 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C2983550 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1182/blood-2005-11-4385 |
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