Academic Journal
Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms
| العنوان: | Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms |
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| المؤلفون: | Comai, Stefano, Nunez, Nicolas, Atkin, Tobias, Ghabrash, Maykel F, Zakarian, Rita, Fielding, Allan, Saint-Laurent, Marie, Low, Nancy, Sauber, Garrett, Ragazzi, Eugenio, Hillard, Cecilia J, Gobbi, Gabriella |
| المساهمون: | Comai, Stefano, Nunez, Nicola, Atkin, Tobia, Ghabrash, Maykel F, Zakarian, Rita, Fielding, Allan, Saint-Laurent, Marie, Low, Nancy, Sauber, Garrett, Ragazzi, Eugenio, Hillard, Cecilia J, Gobbi, Gabriella |
| بيانات النشر: | BMC |
| سنة النشر: | 2024 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Biomarker, Depression, Endocannabinoid, Kynurenine pathway, Serotonin |
| الوصف: | BackgroundThe endocannabinoid (eCB) system and the serotonin (5-HT) are both implicated in the severity of the depression. 5-HT is synthesized from the amino acid tryptophan (Trp), which is also a precursor for kynurenine (Kyn) whose production is increased at the expense of 5-HT in depressed patients. No clinical studies have investigated the crosstalk between the eCB system and the Trp/5-HT/Kyn pathways. Here, we hypothesized that the eCB system is associated with an enhanced Kyn production in relation to the severity of depressive symptoms.MethodsEighty-two subjects (51 patients with a diagnosis of depressive disorder (DSM-5) and 31 healthy volunteers), were assessed with the Montgomery-angstrom sberg Depression Rating Scale (MADRS), Beck Depression Scale, and Global Clinical Impression. Serum concentrations of eCBs (N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG)); structurally related fatty acyl compounds 2-oleoylglycerol (2-OG), oleoylethanolamide (OEA), and palmitoylethanolamide (PEA); Trp, Kyn, Kyn/Trp ratio (an index of Trp degradation into Kyn) and 5-HT were also determined.ResultsFollowing a principal component analysis including the severity of depression, Kyn and the Kyn/Trp ratio appear to be directly associated with 2-AG, AEA, and PEA. Interestingly, these biomarkers also permitted to distinguish the population into two main clusters: one of individuals having mild/severe depressive symptoms and the other with an absence of depressive symptoms. Using parametric analysis, higher serum levels of 2-AG, Kyn, and the ratio Kyn/Trp and lower levels of Trp and 5-HT were found in individuals with mild/severe depressive symptoms than in those without depressive symptoms. While in asymptomatic people, PEA was directly associated to Trp, and OEA indirectly linked to 5-HT, in individuals with depressive symptoms, these correlations were lost, and instead, positive correlations between AEA and 2-AG, PEA and AEA, and PEA vs 2-AG and OEA concentrations were found.ConclusionsParametric and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38273283; info:eu-repo/semantics/altIdentifier/wos/WOS:001151393000005; volume:22; issue:1; journal:BMC MEDICINE; https://hdl.handle.net/11577/3513562; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85182980042 |
| DOI: | 10.1186/s12916-024-03248-8 |
| الاتاحة: | https://hdl.handle.net/11577/3513562 https://doi.org/10.1186/s12916-024-03248-8 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C294AA13 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12916-024-03248-8 |
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