Academic Journal
Amygdala Kindling in the WAG/Rij Rat Model of Absence Epilepsy
| العنوان: | Amygdala Kindling in the WAG/Rij Rat Model of Absence Epilepsy |
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| المؤلفون: | Aker, Rezzan Gülhan, Yananli, Hasan Raci, Gurbanova, Ayten Azizova, Özkaynakçi, Aydan Ergün, Ateş, Nurbay, van Luijtelaar, Gilles, Onat, Filiz Yilmaz |
| المصدر: | Epilepsia ; volume 47, issue 1, page 33-40 ; ISSN 0013-9580 1528-1167 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2006 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Summary: Purpose: The kindling model in rats with genetic absence epilepsy is suitable for studying mechanisms involved in the propagation and generalization of seizure activity in the convulsive and nonconvulsive components of epilepsy. In the present study, we compared the amygdala kindling rate and afterdischarge characteristics of the nonepileptic Wistar control rat with a well‐validated model of absence epilepsy, the WAG/Rij rat, and demonstrated the effect of amygdala kindling on spike‐and‐wave discharges (SWDs) in the WAG/Rij group. Methods: Electrodes were stereotaxically implanted into the basolateral amygdala of rats for stimulation and recording and into the cortex for recording. After a recovery period, the animals were stimulated at their afterdischarge thresholds. EEG was recorded to analyze SWDs and afterdischarge durations. The seizure severity was evaluated by using Racine's 5‐stage scale. Results: All nonepileptic control and four of seven WAG/Rij animals reached a stage 5 seizure state, whereas three animals failed to reach stage 3, 4, or 5 and stayed at stage 2 after application of 30 stimulations. Interestingly, WAG/Rij rats, resistant to kindling, demonstrated a significantly longer duration of SWDs on the first day of the experiment before kindling stimulation than did the kindled WAG/Rij animals. Additionally, the cumulative total duration and the number of SWDs after the kindling stimulation were statistically increased compared with SWDs before kindling stimulation. Conclusions : The results of our study demonstrate that the progress of amygdala kindling is changed in rats with genetic absence epilepsy, perhaps as a consequence of the hundreds of daily SWDs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1528-1167.2006.00367.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1528-1167.2006.00367.x http://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1528-1167.2006.00367.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1528-1167.2006.00367.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.C27AE3D6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1528-1167.2006.00367.x |
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