التفاصيل البيبلوغرافية
| العنوان: |
Table_1_Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation.DOCX |
| المؤلفون: |
Siqing Ma (11498599), Heng Xu (244639), Weihua Huang (408343), Yongchao Gao (2139724), Honghao Zhou (405068), Xiong Li (112522), Wei Zhang (405) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Physiology, Exercise Physiology, Nutritional Physiology, Reproduction, Cell Physiology, Systems Physiology, Animal Physiology - Biophysics, Animal Physiology - Cell, Animal Physiology - Systems, Comparative Physiology, Physiology not elsewhere classified, chrysophanol, cisplatin, acute kidney injury, oxidative stress, apoptosis, inflammation |
| الوصف: |
Cisplatin (CDDP) is one of the most frequently prescribed chemotherapy medications. However, its nephrotoxicity which often leads to acute kidney injury (AKI), greatly limits its clinical application. Chrysophanol (CHR), a mainly active anthraquinone ingredient, possesses various biological and pharmacological activities. In this study, we aimed to investigate the underlying protective mechanisms of CHR against CDDP-induced AKI (CDDP-AKI) using C57BL/6 mouse and human proximal tubule epithelial cells. In vivo, we found that pre-treatment with CHR greatly relieved CDDP-AKI and improved the kidney function and morphology. The mechanistic studies indicated that it might alleviate CDDP-AKI by inhibiting oxidative stress, apoptosis, and IKKβ/IκBα/p65/transcription factor nuclear kappa B (NF-κB) inflammation signaling pathway induced by CDDP. Moreover, we found that the cell viability of HK2 cells reduced by CDDP was partially rescued by CHR pre-incubation. Flow cytometry results further indicated that CHR pre-incubation suppressed CDDP induced cellular reactive oxygen species (ROS) generation and inhibited cell apoptosis in a dose-dependent manner. In summary, our results suggested that CHR might be a novel therapy for CDDP-induced AKI. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Table_1_Chrysophanol_Relieves_Cisplatin-Induced_Nephrotoxicity_via_Concomitant_Inhibition_of_Oxidative_Stress_Apoptosis_and_Inflammation_DOCX/17152559 |
| DOI: |
10.3389/fphys.2021.706359.s001 |
| الاتاحة: |
https://doi.org/10.3389/fphys.2021.706359.s001 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.C262A69C |
| قاعدة البيانات: |
BASE |