Academic Journal
Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle
| العنوان: | Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle |
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| المؤلفون: | Miraglia, Maria Cruz, Barrios-Benito, Melanie, Galdo Novo, Sabrina, Bucafusco, Danilo, Taffarel, Ana, Capozzo, Alejandra, Borca, Manuel Victor, Perez Filgueira, Daniel Mariano |
| المصدر: | Viruses 16 (11) : 1732 (November 2024) |
| بيانات النشر: | MDPI |
| سنة النشر: | 2024 |
| المجموعة: | Inta Digital (ID - Instituto Nacional de Tecnología Agropecuaria) |
| مصطلحات موضوعية: | Foot-and-mouth Disease, Cattle, Immunization, Neutralization, Serotypes, Fiebre Aftosa, Ganado Bovino, Inmunización, Neutralización, Serotipos |
| الوصف: | The high antigenic variability of the foot-and-mouth disease virus (FMDV) represents a challenge for developing prophylactic strategies, stressing the need for research into vaccines offering broad protection against a range of virus strains. Here, the heterotypic cross-reaction using different vaccine schemes against serotype O strains was studied, evaluating the impact of revaccination, antigen dose, and incorporation of additional FMDV serotypes. Naïve cattle were immunized with seven distinct FMDV vaccines, receiving three doses of the same formulation at 0, 28, and 56 days post-primary vaccination (dpv). Serum samples were collected up to 70 dpv and tested by a virus-neutralizing test against serotype O strains from a South American lineage and two strains representative of two Asian lineages. Our results showed that vaccines containing the ME-SA topotype O1/Campos strain developed cross-neutralizing responses against the two Asian viruses after the first vaccination. In contrast, significant heterotypic neutralizing antibody titers against the homologous topotype strain were only found after the second vaccination, indicating that the phylogenic relationship may differ from the antigenic profiles for these two viruses. The amount of the O1/Campos strain and the revaccination were essential factors for neutralization against the homologous- and heterologous-type O FMDV viruses. The strain composition of the vaccine was only relevant for cross-neutralization against one of the Asian strains, suggesting potential intra-serotypic divergences for this pattern. Keywords: foot-and-mouth disease; cattle; heterologous protection ; Instituto de Virología ; Fil: Miraglia, Maria Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina ; Fil: Miraglia, Maria Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Barrios-Benito, Melanie. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); Argentina ; Fil: Galdo ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repograntAgreement/INTA/2023-PD-L01-I113, Herramientas de estudio de la Patogenia e Inmunidad en agentes infecciosos y tóxicos que aporten a la sustentabilidad de la producción pecuaria en el marco de Una Salud; http://hdl.handle.net/20.500.12123/20461; https://doi.org/10.3390/v16111732 |
| DOI: | 10.3390/v16111732 |
| الاتاحة: | https://hdl.handle.net/20.500.12123/20461 https://www.mdpi.com/1999-4915/16/11/1732 https://doi.org/10.3390/v16111732 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-sa/4.0/ ; Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
| رقم الانضمام: | edsbas.C23D79DE |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/v16111732 |
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