Academic Journal
Cut and Paste for Cancer Treatment: A DNA Nanodevice that Cuts Out an RNA Marker Sequence to Activate a Therapeutic Function
| العنوان: | Cut and Paste for Cancer Treatment: A DNA Nanodevice that Cuts Out an RNA Marker Sequence to Activate a Therapeutic Function |
|---|---|
| المؤلفون: | Molden, Tatiana A., Niccum, Caitlyn T., Kolpashchikov, Dmitry M. |
| المصدر: | Angewandte Chemie International Edition ; volume 59, issue 47, page 21190-21194 ; ISSN 1433-7851 1521-3773 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | DNA nanotechnology uses oligonucleotide strands to assemble molecular structures capable of performing useful operations. Here, we assembled a multifunctional prototype DNA nanodevice, DOCTR, that recognizes a single nucleotide mutation in a cancer marker RNA. The nanodevice then cuts out a signature sequence and uses it as an activator for a “therapeutic” function, namely, the cleavage of another RNA sequence. The proposed design is a prototype for a gene therapy DNA machine that cleaves a housekeeping gene only in the presence of a cancer‐causing point mutation and suppresses cancer cells exclusively with minimal side effects to normal cells. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/anie.202006384 |
| الاتاحة: | http://dx.doi.org/10.1002/anie.202006384 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.202006384 https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202006384 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/anie.202006384 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.C1E049B4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/anie.202006384 |
|---|