التفاصيل البيبلوغرافية
| العنوان: |
Wnt/β-catenin signaling induces axial elasticity patterns of Hydra extracellular matrix |
| المؤلفون: |
Veschgini, Mariam, Suzuki, Ryo, Kling, Svenja, Petersen, O., Hendrik, Bergheim, Gideon, Bruno, Abuillan, Wasim, Linke, Philipp, Kaufmann, Stefan, Burghammer, Manfred, Engel, Ulrike, Stein, Frank, Özbek, Suat, Holstein, W., Thomas, Tanaka, Motomu |
| المساهمون: |
鈴木, 量, 田中, 求, 10768071, 00706814 |
| بيانات النشر: |
Elsevier BV |
| سنة النشر: |
2023 |
| المجموعة: |
Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ |
| مصطلحات موضوعية: |
Histology, Microscopic anatomy, Zoology, Molecular biology |
| الوصف: |
The extracellular matrix (ECM) plays crucial roles in animal development and diseases. Here, we report that Wnt/β-catenin signaling induces the ECM remodeling during Hydra axis formation. We determined the micro- and nanoscopic arrangement of fibrillar type I collagen along Hydra’s body axis using high-resolution microscopy and X-ray scattering. Elasticity mapping of the ECM ex vivo revealed distinctive elasticity patterns along the body axis. A proteomic analysis of the ECM showed that these elasticity patterns correlate with a gradient-like distribution of metalloproteases along the body axis. Activation of the Wnt/β-catenin pathway in wild-type and transgenic animals alters these patterns toward low ECM elasticity patterns. This suggests a mechanism whereby high protease activity under control of Wnt/β-catenin signaling causes remodeling and softening of the ECM. This Wnt-dependent spatiotemporal coordination of biochemical and biomechanical cues in ECM formation was likely a central evolutionary innovation for animal tissue morphogenesis. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
2589-0042 |
| Relation: |
http://hdl.handle.net/2433/284912; iScience; 26; 106416 |
| الاتاحة: |
http://hdl.handle.net/2433/284912 |
| Rights: |
© 2023 The Authors. ; This is an open access article under the CC BY-NC-ND license. ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: |
edsbas.C1DE98C1 |
| قاعدة البيانات: |
BASE |
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