Academic Journal
Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria
| العنوان: | Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria |
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| المؤلفون: | Kingston, Hugh W. F., Ghose, Aniruddha, Rungpradubvong, Voravut, Satitthummanid, Sudarat, Herdman, M. Trent, Plewes, Katherine, Ishioka, Haruhiko, Leopold, Stije J., Sinha, Ipsita, Intharabut, Benjamas, Piera, Kim, McNeil, Yvette, Mohanty, Sanjib, Maude, Richard J., White, Nicholas J., Day, Nicholas P. J., Yeo, Tsin Wen, Md Amir Hossain, Anstey, Nicholas M., Dondorp, Arjen M. |
| المساهمون: | Lee Kong Chian School of Medicine (LKCMedicine) |
| سنة النشر: | 2020 |
| المجموعة: | DR-NTU (Digital Repository at Nanyang Technological University, Singapore) |
| مصطلحات موضوعية: | Science::Medicine, Severe Malaria, Hemodynamics |
| الوصف: | In severe falciparum malaria, unlike sepsis, hypotension on admission is uncommon. We hypothesized that low nitric oxide bioavailability due to the presence of cell-free hemoglobin (CFH) increases vascular tone in severe malaria. ; Published version ; . This work was supported by the Australian National Health and Medical Research Council (grants 605807, 496600, and 1037304 and fellowships 1042072 [to N. M. A.] and 605831 [to T. W. Y.]); the Australian government (UPRS and PIRTS scholarship to H. W. K.); University College, Oxford (Radcliffe Travelling Fellowship to MTH); and the Wellcome Trust, as part of the Wellcome Thailand Trust Major Oversees Programme funding |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0022-1899 |
| Relation: | Journal of Infectious Diseases; Kingston, H. W. F., Ghose, A., Rungpradubvong, V., Satitthummanid, S., Herdman, M. T., Plewes, K., Ishioka, H., Leopold, S. J., Sinha, I., Intharabut, B., Piera, K., McNeil, Y., Mohanty, S., Maude, R. J., White, N. J., Day, N. P. J., Yeo, T. W., Md Amir Hossain, Anstey, N. M. & Dondorp, A. M. (2020). Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria. Journal of Infectious Diseases, 221(1), 127-137. https://dx.doi.org/10.1093/infdis/jiz359; https://hdl.handle.net/10356/152850; 2-s2.0-85076505939; 221; 127; 137 |
| DOI: | 10.1093/infdis/jiz359 |
| الاتاحة: | https://hdl.handle.net/10356/152850 https://doi.org/10.1093/infdis/jiz359 |
| Rights: | © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| رقم الانضمام: | edsbas.C1D30083 |
| قاعدة البيانات: | BASE |
| تدمد: | 00221899 |
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| DOI: | 10.1093/infdis/jiz359 |