Academic Journal
Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities
| العنوان: | Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities |
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| المؤلفون: | Wang, Huan, Lin, Shiqi, Wu, Xiying, Jiang, Kuan, Lu, Huiping, Zhan, Changyou |
| المساهمون: | National Natural Science Foundation of China, Ministry of Science and Technology |
| المصدر: | Advanced Science ; volume 10, issue 20 ; ISSN 2198-3844 2198-3844 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Liposomes have received tremendous attention as a class of versatile pharmaceutical vehicles of great potential over the past several decades. However, the application of liposomes encounters major challenges due to the knowledge gaps in their in vivo delivery process. Immunoglobulin M (IgM) displays both pervasiveness and complexity in regulating the biological functions as well as eliciting adverse effects of liposomes. Understanding, mitigating, and exploiting the duality of IgM are prerequisites for achieving various biomedical applications of liposomes. In this review, the intricate relationship between liposomes and their biological environments has been summarized, with an emphasis on the regulatory effects of IgM on in vivo performance of liposomes. Corresponding solutions have also been discussed to evade IgM‐mediated opsonization for safe and efficient drug delivery. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/advs.202301777 |
| الاتاحة: | http://dx.doi.org/10.1002/advs.202301777 https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202301777 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.C1ABFC29 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/advs.202301777 |
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