Academic Journal
Preferential usage of T-cell receptor V beta 17 by dengue virus-specific human T lymphocytes in a donor with immunity to dengue virus type 4
| العنوان: | Preferential usage of T-cell receptor V beta 17 by dengue virus-specific human T lymphocytes in a donor with immunity to dengue virus type 4 |
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| المؤلفون: | Okamoto, Y, Gagnon, S J, Kurane, I, Leporati, A M, Ennis, F A |
| المصدر: | Journal of Virology ; volume 68, issue 11, page 7614-7619 ; ISSN 0022-538X 1098-5514 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 1994 |
| الوصف: | In order to better understand human T-cell responses to dengue viruses (DV), we analyzed T-cell receptor (TCR) V beta gene usage in DV-specific T lymphocytes. Peripheral blood T lymphocytes from a DV type 4 immune donor were stimulated in vitro with DV type 4 antigen, and TCR usage was examined by reverse transcriptase PCR. TCR V beta 17 was preferentially used (P = 0.020) among T cells stimulated by DV type 4 in bulk culture. Furthermore, 8 of 19 DV type 4-specific CD4+ T-cell clones established from the peripheral blood mononuclear cells expressed V beta 17 (P = 0.008). Preferential usage of TCR V alpha was not found among T cells expressing V beta 17. These results indicate that there is preferential usage of TCR V beta 17 among DV-specific T cells in this donor and suggest that T cells with certain TCRs may be important in immune responses to DV. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/jvi.68.11.7614-7619.1994 |
| الاتاحة: | http://dx.doi.org/10.1128/jvi.68.11.7614-7619.1994 https://journals.asm.org/doi/pdf/10.1128/jvi.68.11.7614-7619.1994 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.C18A616 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/jvi.68.11.7614-7619.1994 |
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