Academic Journal
Tetrazine-Based Ratiometric Nitric Oxide Sensor Identifies Endogenous Nitric Oxide in Atherosclerosis Plaques by Riding Macrophages as a Smart Vehicle
| العنوان: | Tetrazine-Based Ratiometric Nitric Oxide Sensor Identifies Endogenous Nitric Oxide in Atherosclerosis Plaques by Riding Macrophages as a Smart Vehicle |
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| المؤلفون: | Lin Zhou, Zehui Wang, Lai Wang, Xinfu Zhang, Yi Xiao |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Medicine, Molecular Biology, Inorganic Chemistry, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, serious cardiovascular diseases, two lesion stages, smart vehicle atherosclerosis, probe within macrophages, smart strategy, probe confirmed, lesion progressed, vivo level, universal platforms, riding macrophages, reactive molecules, ratiometric signals, orthogonal labeling, mouse model, micrometers specifically, microenvironmental factors, increased significantly, highly related, current research, blood vessels, based ratiometric, atherosclerosis plaques |
| الوصف: | Atherosclerosis (AS) is the formation of plaques in blood vessels, which leads to serious cardiovascular diseases. Current research has disclosed that the formation of AS plaques is highly related to the foaming of macrophages. However, there is a lack of detailed molecular biological mechanisms. We proposed a “live sensor” by grafting a tetrazine-based ratiometric NO probe within macrophages through metabolic and bio-orthogonal labeling. This “live sensor” was proved to target the AS plaques with a diameter of only tens of micrometers specifically and visualized endogenous NO at two lesion stages in the AS mouse model. The ratiometric signals from the probe confirmed the participation of NO during AS and indicated that the generation of endogenous NO increased significantly as the lesion progressed. Our proposal of this “live sensor” provided a native and smart strategy to target and deliver small molecular probes to the AS plaques at the in vivo level, which can be used as universal platforms for the detection of reactive molecules or microenvironmental factors in AS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Tetrazine-Based_Ratiometric_Nitric_Oxide_Sensor_Identifies_Endogenous_Nitric_Oxide_in_Atherosclerosis_Plaques_by_Riding_Macrophages_as_a_Smart_Vehicle/24800487 |
| DOI: | 10.1021/jacs.3c12181.s001 |
| الاتاحة: | https://doi.org/10.1021/jacs.3c12181.s001 https://figshare.com/articles/journal_contribution/Tetrazine-Based_Ratiometric_Nitric_Oxide_Sensor_Identifies_Endogenous_Nitric_Oxide_in_Atherosclerosis_Plaques_by_Riding_Macrophages_as_a_Smart_Vehicle/24800487 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.C16DB0EE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/jacs.3c12181.s001 |
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