Academic Journal
Impact of Low-Level Viraemia on Virological Failure in HIV-1-Infected Patients with Stable Antiretroviral Treatment
| العنوان: | Impact of Low-Level Viraemia on Virological Failure in HIV-1-Infected Patients with Stable Antiretroviral Treatment |
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| المؤلفون: | Navarro, Jordi, Caballero, Estrella, Curran, Adrian, Burgos, Joaquin, Ocaña, Inma, Falcó, Vicenç, Torrella, Ariadna, Pérez, Mercè, Ribera, Esteban, Crespo, Manuel |
| المصدر: | Antiviral Therapy ; volume 21, issue 4, page 345-352 ; ISSN 1359-6535 2040-2058 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2015 |
| الوصف: | Background Low-level viraemia (LLV) occurs in 20–40% of patients achieving viral suppression with antiretroviral therapy (ART). The risk of virological failure (VF: confirmed HIV RNA >200 copies/ml) in these patients is still a matter of debate. Methods This is a prospective cohort study in HIV-infected adults attending the HIV clinic of a tertiary care hospital in Spain. Patients with HIV RNA <25 copies/ml and stable ART for at least 6 months presenting LLV (defined as HIV RNA between 25–1,000 copies/ml) from January 2011 to January 2013 were included and followed until VF or end of follow-up in June 2014. Results A total of 300 out of 1,733 (17.3%) patients with undetectable viraemia for 4.2 years showed LLV: 25–50 copies/ml in 167 (55.7%) patients, 51–200 copies/ml in 111 (37%) and 201–1,000 copies/ml in 22 (7.3%) cases. After a median follow-up of 2.6 years, 23 (7.7%) patients presented VF. No patient with a single or multiple unconfirmed LLV went on to develop VF. HIV RNA >200 copies/ml (HR 59.6; 95% CI 15.7, 227), ritonavir-boosted protease inhibtor (PI/r)-based dual therapy (HR 10.2; 95% CI 2.1, 49.8) and PI/r monotherapy (HR 7.9; 95% CI 1.4, 43.3) were associated with VF. Persistent LLV, defined as HIV RNA <200 copies/ml in at least three consecutive samples, for at least 12 weeks, was detected in 27 (1.6%) patients and 14 (51.9%) of those evolved to VF. Conclusions Nearly one-fifth of patients on suppressive ART showed LLV and 8% of them developed VF. HIV RNA >200 copies/ml was the strongest predictor of VF. Over half of patients with persistent viraemia <200 copies/ml showed VF. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.3851/imp3023 |
| DOI: | 10.3851/IMP3023 |
| الاتاحة: | http://dx.doi.org/10.3851/imp3023 http://journals.sagepub.com/doi/pdf/10.3851/IMP3023 |
| Rights: | http://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.C121A1E0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3851/imp3023 |
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