Academic Journal
Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children
| العنوان: | Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children |
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| المؤلفون: | Halasa, Natasha B, Spieker, Andrew J, Young, Cameron C, Olson, Samantha M, Newhams, Margaret M, Amarin, Justin Z, Moffitt, Kristin L, Nakamura, Mari M, Levy, Emily R, Soma, Vijaya L, Talj, Rana, Weiss, Scott L, Fitzgerald, Julie C, Mack, Elizabeth H, Maddux, Aline B, Schuster, Jennifer E, Coates, Bria M, Hall, Mark W, Schwartz, Stephanie P, Schwarz, Adam J, Kong, Michele, Spinella, Philip C, Loftis, Laura L, McLaughlin, Gwenn E, Hobbs, Charlotte V, Rowan, Courtney M, Bembea, Melania M, Nofziger, Ryan A, Babbitt, Christopher J, Bowens, Cindy, Flori, Heidi R, Gertz, Shira J |
| المصدر: | NYMC Faculty Publications |
| بيانات النشر: | Touro Scholar |
| سنة النشر: | 2023 |
| المجموعة: | Touro College & University System: Touro Scholar |
| مصطلحات موضوعية: | COVID-19, SARS-CoV-2, children, influenza, intensive care units, Faculty, Medicine and Health Sciences |
| الوصف: | BACKGROUND: Clinical differences between critical illness from influenza infection vs coronavirus disease 2019 (COVID-19) have not been well characterized in pediatric patients. METHODS: We compared demographics, clinical characteristics, and outcomes of US children (aged 8 months to 17 years) admitted to the intensive care or high-acuity unit with influenza or COVID-19. Using mixed-effects models, we assessed the odds of death or requiring life support for influenza vs COVID-19 after adjustment for age, sex, race and Hispanic origin, and underlying conditions including obesity. RESULTS: Children with influenza (n = 179) were younger than those with COVID-19 (n = 381; median, 5.2 years vs 13.8 years), less likely to be non-Hispanic Black (14.5% vs 27.6%) or Hispanic (24.0% vs 36.2%), and less likely to have ≥1 underlying condition (66.4% vs 78.5%) or be obese (21.4% vs 42.2%), and a shorter hospital stay (median, 5 days vs 7 days). They were similarly likely to require invasive mechanical ventilation (both 30.2%), vasopressor support (19.6% and 19.9%), or extracorporeal membrane oxygenation (2.2% and 2.9%). Four children with influenza (2.2%) and 11 children with COVID-19 (2.9%) died. The odds of death or requiring life support in children with influenza vs COVID-19 were similar (adjusted odds ratio, 1.30; 95% confidence interval, .78-2.15; P = .32). CONCLUSIONS: Despite differences in demographics and clinical characteristics of children with influenza or COVID-19, the frequency of life-threatening complications was similar. Our findings highlight the importance of implementing prevention measures to reduce transmission and disease severity of influenza and COVID-19. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://touroscholar.touro.edu/nymc_fac_pubs/4424; https://pubmed.ncbi.nlm.nih.gov/35717646/?myncbishare=nymclib |
| DOI: | 10.1093/cid/ciac477 |
| الاتاحة: | https://touroscholar.touro.edu/nymc_fac_pubs/4424 https://doi.org/10.1093/cid/ciac477 https://pubmed.ncbi.nlm.nih.gov/35717646/?myncbishare=nymclib |
| رقم الانضمام: | edsbas.C104C49E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/cid/ciac477 |
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