التفاصيل البيبلوغرافية
| العنوان: |
High‑ Z ′ Crystal Structure of Tricyclic Imidazonaphthyridine Derivatives and the Thermal Profiles of Their Polymorphs |
| المؤلفون: |
Shota Matsumoto (6754745), Tomohiro Umeno (2884514), Kazuteru Usui (1547713), Satoru Karasawa (1812145) |
| سنة النشر: |
1753 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Physiology, Cancer, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, 4- anilino moiety, polymorph, INA, imidazonaphthyridine framework, tricyclic imidazonaphthyridine deri., crystal structures |
| الوصف: |
The crystal structures and thermal profiles of three crystal polymorphs of tricyclic imidazonaphthyridine derivatives ( INA ) were investigated. The aniline derivative INA–AN , in which a 4-anilino moiety was introduced at position 9 of the imidazonaphthyridine framework, yielded a nonplanar curved structure between imidazonaphthyridine and aniline. Three crystals ( INA–AN-α ( I 4 1 / a with Z ′ = 1) as an emissive polymorph, as well as INA–AN-β1 and INA–AN-β2 ( Pc with Z ′ = 4) as nonemissive polymorphs) were obtained. The polymorphs comprised multiple-hydrogen-bond networks. INA–AN-β1 and -β2 crystallized into different polymorphs via recrystallization: INA–AN-β1 and -β2 were obtained from the solvent, as well as via melting and recrystallization processes. Notably, the crystal structures and parameters of INA–AN-β1 and -β2 largely corresponded, although their thermal behaviors were significantly different: INA–AN-β1 underwent a thermal crystal transformation, yielding INA–AN-α at ∼185 °C, while INA–AN-β2 readily melted at ∼190 °C. These distinct profiles indicated that the subtle distinct molecular arrangements, as well as crystal packings, might account for the different thermal profiles of INA–INA-β polymorphs. Interestingly, in addition to INA–AN-β polymorphs, an imidazonaphthyridine framework bearing an N , N -dimethylamine moiety, INA–DMA , crystallized in the P 1̅ space group with Z ′ = 4, indicating that the INA framework containing an aromatic ring afforded high- Z ′ crystal structures. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/High_i_Z_i_Crystal_Structure_of_Tricyclic_Imidazonaphthyridine_Derivatives_and_the_Thermal_Profiles_of_Their_Polymorphs/15087052 |
| DOI: |
10.1021/acs.cgd.1c00585.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.cgd.1c00585.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.C0F64BF0 |
| قاعدة البيانات: |
BASE |