Academic Journal
Dendritic cells in reflectance confocal microscopy are a clue for early melanoma diagnosis in extrafacial flat pigmented melanocytic lesions
| العنوان: | Dendritic cells in reflectance confocal microscopy are a clue for early melanoma diagnosis in extrafacial flat pigmented melanocytic lesions |
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| المؤلفون: | Guiducci L., Kaleci S., Chester J., Longo C., Ciardo S., Farnetani F., Pellacani G. |
| المساهمون: | Guiducci, L., Kaleci, S., Chester, J., Longo, C., Ciardo, S., Farnetani, F., Pellacani, G. |
| سنة النشر: | 2022 |
| المجموعة: | Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
| مصطلحات موضوعية: | dendritic cell, extrafacial pigmented lesion, melanoma, nevi, reflectance confocal microscopy |
| الوصف: | Differential diagnosis of extrafacial flat pigmented lesions with dermoscopic reticular and/or homogeneous pattern is challenging. Dendritic cells upon reflectance confocal microscopy (RCM) still represent a pitfall. This study aims to determine the role of dendritic cells upon RCM in the epidermis and dermo-epidermal junction (DEJ), together with common RCM features for melanoma and nevi, in dermoscopically equivocal extrafacial flat pigmented lesions. A retrospective evaluation of RCM images of melanocytic extrafacial flat pigmented lesions with reticular and/or homogeneous dermoscopic pattern and with histopathological diagnosis, was performed. A multivariate model of RCM features was used to obtain a score of independent risk factors. A total of 698 lesions were included. Increasing patient age, epidermal dendritic cells, many dendritic cells in the DEJ (>30%) and many (>5/mm2) round atypical cells were independent risk factors for melanoma. Edged papillae and melanophages were indicative of nevus. A score based on these features was developed to assist in melanoma differential diagnosis. The RCM observation of abundant (>30%) dendritic cells in the DEJ is highly suggestive of malignity. This independent risk factor should also be considered for improved differential diagnosis of extrafacial melanoma. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35220636; info:eu-repo/semantics/altIdentifier/wos/WOS:000764756400001; volume:31; issue:7; firstpage:1048; lastpage:1055; journal:EXPERIMENTAL DERMATOLOGY; http://hdl.handle.net/11380/1270327; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85125588628 |
| DOI: | 10.1111/exd.14553 |
| الاتاحة: | http://hdl.handle.net/11380/1270327 https://doi.org/10.1111/exd.14553 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C0C3D77B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/exd.14553 |
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