Academic Journal
Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations
| العنوان: | Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations |
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| المؤلفون: | García Vázquez, Verónica, Calvo, Felipe A, Ledesma Carbayo, María Jesús, Vicente Solé, Claudio, Calvo Haro, José Antonio, Desco Menéndez, Manuel, Pascau González-Garzón, Javier |
| المساهمون: | Ministerio de Economía y Competitividad (España) |
| بيانات النشر: | PLOS |
| سنة النشر: | 2020 |
| المجموعة: | Universidad Carlos III de Madrid: e-Archivo |
| مصطلحات موضوعية: | Computed axial tomography, Tissue distribution, Surgical and invasive medical procedures, Breast cancer, Radiation therapy, Cancer treatment, Image processing, Surgical oncology, Biología y Biomedicina |
| الوصف: | In intraoperative electron radiation therapy (IOERT) the energy of the electron beam is selected under the conventional assumption of water-equivalent tissues at the applicator end. However, the treatment field can deviate from the theoretic flat irradiation surface, thus altering dose profiles. This patient-based study explored the feasibility of acquiring intraoperative computed tomography (CT) studies for calculating three-dimensional dose distributions with two factors not included in the conventional assumption, namely the air gap from the applicator end to the irradiation surface and tissue heterogeneity. In addition, dose distributions under the conventional assumption and from preoperative CT studies (both also updated with intraoperative data) were calculated to explore whether there are other alternatives to intraoperative CT studies that can provide similar dose distributions. The IOERT protocol was modified to incorporate the acquisition of intraoperative CT studies before radiation delivery in six patients. ; This study was supported by Ministerio de Ciencia, Innovación y Universidades (http://www.ciencia.gob.es) [grant number TEC2013–48251-C2 to JP, VG-V and MJL-C], co-funded by European Regional Development Fund (ERDF), “A way of making Europe” (https://ec.europa.eu/regional_policy/en/funding/erdf); by Ministerio de Ciencia, Innovación y Universidades (http://www.ciencia.gob.es), Instituto de Salud Carlos III (https://www.isciii.es) [grant numbers DTS14/00192 to JP, VG-V and FAC; PI15/02121 to FAC and JC-H; PI18/01625 to JP], co-funded by European Regional Development Fund (ERDF), “A way of making Europe” (https://ec.europa.eu/regional_policy/en/funding/erdf); and by Comunidad de Madrid (http://www.comunidad.madrid) [grant number TOPUS-CM S2013/MIT3024 to JP], co-funded by European Structural and Investment Fund (https://ec.europa.eu/info/funding-tenders/funding-opportunities/funding-programmes/overview-funding-programmes_en). The CNIC is supported by the Ministerio de Ciencia, Innovación y ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | Gobierno de España. TEC2013-48251-C2-1-R; https://www.doi.org/10.6084/m9.figshare.9248897; García-Vázquez V, Calvo FA, Ledesma-Carbayo MJ, Sole CV, Calvo-Haro J, Desco M, et al. (2020) Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations. PLoS ONE 15(1): e0227155; http://hdl.handle.net/10016/31915; https://doi.org/10.1371/journal.pone.0227155; 1(e0227155); PLoS One; 15; AR/0000024190 |
| DOI: | 10.1371/journal.pone.0227155 |
| الاتاحة: | http://hdl.handle.net/10016/31915 https://doi.org/10.1371/journal.pone.0227155 |
| Rights: | © 2020 García-Vázquez et al. ; Atribución 3.0 España ; http://creativecommons.org/licenses/by/3.0/es/ ; open access |
| رقم الانضمام: | edsbas.C0AB08B0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0227155 |